Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1072882..1073502 Replicon chromosome
Accession NZ_CP058253
Organism Enterobacter roggenkampii strain ED5

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag ED5_RS05005 Protein ID WP_008499287.1
Coordinates 1072882..1073100 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag ED5_RS05010 Protein ID WP_008499288.1
Coordinates 1073128..1073502 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ED5_RS04975 1068895..1069155 + 261 WP_032664013.1 type B 50S ribosomal protein L31 -
ED5_RS04980 1069158..1069298 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
ED5_RS04985 1069295..1070005 - 711 WP_045371775.1 GNAT family N-acetyltransferase -
ED5_RS04990 1070107..1071567 + 1461 WP_177317161.1 PLP-dependent aminotransferase family protein -
ED5_RS04995 1071539..1072006 - 468 WP_059362219.1 hypothetical protein -
ED5_RS05000 1072124..1072675 - 552 WP_045416680.1 maltose O-acetyltransferase -
ED5_RS05005 1072882..1073100 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
ED5_RS05010 1073128..1073502 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
ED5_RS05015 1074012..1077158 - 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit -
ED5_RS05020 1077181..1078374 - 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T166409 WP_008499287.1 NZ_CP058253:c1073100-1072882 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T166409 NZ_CP074147:c3686165-3685812 [Serratia sp. JSRIV001]
GTGTGGAAGATTAAAACAACGGATACGTTTGACGAGTGGTTCAGCCGGTTGGATGACACTGACAGAGCTTCGGTGCTGGC
GTCACTCATGGTATTACGTGAAAAGGGTCCTCAGTTGCCCAGACCTTATGCCGACACGGTAAAGGGATCGCGCTACAGCA
ACATGAAGGAACTGCGCGTGCAAAGCCGAGGCATACCGATACGGGCATTCTTTGCCTTTGATCCACGCCGTCGCGGTATT
TTGCTTTGTGCTGGTAACAAGGCTGGTAATGAGAAGCGTTTTTATGAGGTGATGATCCCGATTGCCGATCGGGAATTTAC
CCAATTTCTGAATACAGCAGAGAACAAGGAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT166409 WP_008499288.1 NZ_CP058253:c1073502-1073128 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT166409 NZ_CP074147:c3685807-3685505 [Serratia sp. JSRIV001]
ATGGGCAGAACACTGGAACAAATCCTGGCGGAAGAAAAACCCGAGGTAGTGGCCAGCGCTGAGCGCATTGCGGCGGATAC
GCTGCTCAATATTCACCTGGCCGAGCTACGTGAGCGGGTGCAGAAAACCCAGGTTGAAATGGCGCAGGCACTTGGCATCA
AACAACCCACCGTGGCGGGCATGGAAAAACCAGGCCGCGATCTGAAGCTCTCCTCGCTCAAACGCTATATCGAGGCCGCG
GGGGGCAAGCTGCGTCTGGATATAGAGCTGCCAGATGGTTCGCACTATGGGTTTGTTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References