Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 507853..508369 Replicon chromosome
Accession NZ_CP058253
Organism Enterobacter roggenkampii strain ED5

Toxin (Protein)


Gene name relE Uniprot ID A0A0W2HDR3
Locus tag ED5_RS02395 Protein ID WP_008501399.1
Coordinates 508085..508369 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag ED5_RS02390 Protein ID WP_008501400.1
Coordinates 507853..508095 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ED5_RS02375 503943..504683 + 741 WP_008501404.1 KDGP aldolase family protein -
ED5_RS02380 504709..505845 + 1137 WP_177317043.1 lactonase family protein -
ED5_RS02385 505865..507775 + 1911 WP_023326576.1 BglG family transcription antiterminator -
ED5_RS02390 507853..508095 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ED5_RS02395 508085..508369 + 285 WP_008501399.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ED5_RS02400 508373..508837 - 465 WP_023326577.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ED5_RS02405 508943..511081 - 2139 WP_008501397.1 anaerobic ribonucleoside-triphosphate reductase -
ED5_RS02410 511458..513101 - 1644 WP_177317044.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10768.53 Da        Isoelectric Point: 10.3039

>T166407 WP_008501399.1 NZ_CP058253:508085-508369 [Enterobacter roggenkampii]
MTYELEFDPRALKEWSKLGDTVKNQFKKKLAGVLANPRVESARLHNLPDCYKIKLKASGYRLVYQVQDSVITVFVIAVGK
REKSAAYHDANKRL

Download         Length: 285 bp

>T166407 NZ_CP074147:c3359834-3359739 [Serratia sp. JSRIV001]
AACAAACCTTGCATAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCCTTTCCCTAGACCGAGTATAGGAATCG
TACTCGGTCTTTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT166407 WP_008501400.1 NZ_CP058253:507853-508095 [Enterobacter roggenkampii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT166407 NZ_CP074147:3359737-3359825 [Serratia sp. JSRIV001]
ATAAAAAAAGACCGAGTACGATTCCTATACTCGGTCTAGGGAAAGGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTTATGCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W2HDR3

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References