Detailed information of TA system TA166405

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1538321..1539512
• Replicon: chromosome
• Accession: NZ_CP058252
• Organism: Helicobacter pylori strain NP05-124

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: HWU18_RS07375
• Protein ID: WP_120874806.1
• Coordinates: 1538321..1539085 (-)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: HWU18_RS07380
• Protein ID: WP_120874804.1
• Coordinates: 1539075..1539512 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWU18_RS07365	1535643..1536815	+	1173	WP_237004309.1	aminotransferase class V-fold PLP-dependent enzyme	-
HWU18_RS07370	1536912..1538099	+	1188	WP_187922846.1	transcription termination factor NusA	-
HWU18_RS07375	1538321..1539085	-	765	WP_120874806.1	hypothetical protein	Toxin
HWU18_RS07380	1539075..1539512	-	438	WP_120874804.1	Panacea domain-containing protein	Antitoxin
HWU18_RS07385	1540502..1544260	-	3759	WP_237004310.1	class I SAM-dependent DNA methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29755.83 Da
• Isoelectric Point: 8.7940

>T166405 WP_120874806.1 NZ_CP058252:c1539085-1538321 [Helicobacter pylori]
METKEEDKDKKLEEIIVLLCEKGDLSSQTDQIIKDLKEIYEGEYRHKYSKITTIILNSTRDKEQAFMTLTQNIRTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLKDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEKKDKQENFFKKPIFWFNLMVAILFVIGFV
GELHIIQRLVSKYL

Nucleotide

• Length: 765 bp

>T166405 NZ_CP074147:c1402412-1402209 [Serratia sp. JSRIV001]
ATGACAAAAATTGACTATCTGATGCGTTTGCGTAAATGCACCACGATTGAAACCCTTGAGCGCGTGATCGAGAAAAATAA
GTACGAACTTTCTGACGATGAGCTAGAGCTGTTCTACTCTGCCGCCGATCATCGCCTGGCCGAACTGACCATGAACAAGC
TATACGATAAAATTCCGGTCGCCGTTTGGAAATTTGTAAGATAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17275.42 Da
• Isoelectric Point: 6.9814

>AT166405 WP_120874804.1 NZ_CP058252:c1539512-1539075 [Helicobacter pylori]
MVNALELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWRYGPVAREVYYEYRNYGANSIDKPKEEAL
SQNLRKDELETINHSIEKCNKKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIRQEAKQANGN

Nucleotide

• Length: 438 bp

>AT166405 NZ_CP074147:c1402831-1402463 [Serratia sp. JSRIV001]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAACTCAAATTTTTGTGTGAAAATTTGTACGACGAAGGCATCGC
TACCCTGGGTGACAGCCATCACGGCTGGGTAAACGATCCAACGTCCGCCGTCAATCTGCAGCTTAATGAGCTGATCGAAC
ATATTGCTTCGTTTGTAATGAGTTTTAAAATTAAATACATGGACGAAGGTGATTTATCGGAACTGGTCGAAGAGTACCTC
GACGATACCTACACGCTGTTTAGCAGCTACGGTATTAATGACTCCGATTTGCGTCGCTGGCAAAAAACCAAGGCACGCAC
ATTCAGATTGTTCTCAGGAGAGGGCGTCTGTACCACAATGAAAACTTAG