Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3800972..3801501 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag HWS75_RS17885 Protein ID WP_003417760.1
Coordinates 3801244..3801501 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag HWS75_RS17880 Protein ID WP_003417757.1
Coordinates 3800972..3801247 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS17845 3797545..3798234 - 690 WP_003917774.1 BBE domain-containing protein -
HWS75_RS17850 3798421..3798792 - 372 WP_003417739.1 FAD-binding protein -
HWS75_RS17855 3798690..3798908 - 219 WP_157132559.1 hypothetical protein -
HWS75_RS17860 3798935..3799195 - 261 WP_003417741.1 hypothetical protein -
HWS75_RS17865 3799310..3799699 + 390 WP_003417745.1 DUF732 domain-containing protein -
HWS75_RS17870 3799713..3800006 - 294 WP_003417749.1 DUF3017 domain-containing protein -
HWS75_RS17875 3800003..3800848 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
HWS75_RS17880 3800972..3801247 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
HWS75_RS17885 3801244..3801501 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
HWS75_RS17890 3801543..3802733 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
HWS75_RS17895 3802850..3803218 + 369 WP_003417765.1 FHA domain-containing protein -
HWS75_RS17900 3803215..3803766 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
HWS75_RS17905 3803773..3804354 - 582 WP_003417769.1 ATP/GTP-binding protein -
HWS75_RS17910 3804335..3804703 - 369 WP_003417772.1 DUF742 domain-containing protein -
HWS75_RS17915 3804681..3805073 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T166376 WP_003417760.1 NZ_CP058236:3801244-3801501 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T166376 NZ_CP074143:133459-133794 [Serratia sp. JSRIV002]
ATGAAGGCCATCGACAAAATTCCCCATACCGCACCTAACGCCAATCAGGCGTTAGCCGAATACGAGCAATTGCTTACCTG
GTTGCTGAACCACTGTTATGGATTAGAACTCAACGATACGCCGTATCACGACCCACAAGCTATCGCTCAACAGATTGAGT
ACGGAATGACAGTACGGGAAACCATCAACGAGCTGGTCGAGAAATTCGACCTGGTACGTATTGACCGCCCCGGTTTCAGT
CTGCTGGCACAGGACCCTACGCTGAGTGGTGGGGATATGCTACTCGCCCGTAGTGCGTTAGGGCTGCGAAACCCCGTAAA
TCGCCGCCTCGCCTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT166376 WP_003417757.1 NZ_CP058236:3800972-3801247 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT166376 NZ_CP074143:133871-134155 [Serratia sp. JSRIV002]
ATGAAAAATCTCGAACCTGATATCCCACCCACGGCTCCGGTCTGGGGTCTGCAATGTGCTATTACGCCACGTCTGGGGGC
CAGACTGGTTCAACAGGGTCGCCACCTGCATTTTCTGGCTGACCGCGCCGGTTTGATTGGCACGTTCACACCCGAAGCCA
TCAAGGCTCTCGATGTGGCTTTTCCGGTGTTGATTGAACAGTTGGAGAACTATCTGCGATCTGGCGAGCTCGATCCACGT
CGCCAGCATTGTGTCACTGTTCAGCTGTCACCCAGTACAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References