Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3734927..3735601 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag HWS75_RS17670 Protein ID WP_003417282.1
Coordinates 3734927..3735355 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag HWS75_RS17675 Protein ID WP_003417286.1
Coordinates 3735359..3735601 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS17645 3730749..3731150 - 402 WP_003417264.1 cytidine deaminase -
HWS75_RS17650 3731387..3731725 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
HWS75_RS17655 3731722..3732156 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
HWS75_RS17660 3732285..3734057 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
HWS75_RS17665 3734057..3734848 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
HWS75_RS17670 3734927..3735355 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
HWS75_RS17675 3735359..3735601 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
HWS75_RS17680 3735723..3736337 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
HWS75_RS17685 3736334..3736999 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
HWS75_RS17690 3737000..3737533 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
HWS75_RS17695 3737530..3737904 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
HWS75_RS17700 3738001..3739005 - 1005 WP_003914475.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T166375 WP_003417282.1 NZ_CP058236:c3735355-3734927 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T166375 NZ_CP074141:c21817-21530 [Serratia sp. JSRIV004]
ATGACTTATAAGATTGACTTTGACAATGCAGCCTTCAAAGAATGGAAAAAATTAGGTGAGACTGTACGTCAACAGTTAAA
AAAGAAGCTGGCACAGATTGTTGAGGCGCCACGCGTTGAGGCTAACCGACTGCACTCTTTACCTGATTGCTATAAGATCA
AACTCCGCGCATCCGGTTATCGGCTGGTTTACAAGGTCGAAGATGAAACGGTTGTGATCCTCGTCCTTGCTGTAGGTAAA
CGCGAACGGCTGGAAGTTTACAAAGCAGCCGCCACAAGGTTGGGTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT166375 WP_003417286.1 NZ_CP058236:c3735601-3735359 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT166375 NZ_CP074141:c22049-21807 [Serratia sp. JSRIV004]
ATGGGCACAATGAATATTCGTATCGACGATGACTTAAAGGCCCGGGCCGGGGTAGCGCTCGACGGATTGGGGATCACAGC
CTCGGAAGCTGTACGTCTGGTGCTTGAATACGTTGCACAAAATAACCGCCTTCCGGTTCAGGTGGCATTACTGGCTGATG
AAGACGCAGATATCATCGAGCTGGCGCGTGAACGTCTGGCTAATCCTGGCAAACGGATCCGAGTAACACTCGATGACTTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References