Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3204285..3204972 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag HWS75_RS15270 Protein ID WP_003414624.1
Coordinates 3204529..3204972 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag HWS75_RS15265 Protein ID WP_003414620.1
Coordinates 3204285..3204542 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS15245 3199605..3200459 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
HWS75_RS15250 3200515..3201678 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
HWS75_RS15255 3201695..3202909 - 1215 WP_003414610.1 zinc metalloprotease Rip -
HWS75_RS15260 3202917..3204158 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
HWS75_RS15265 3204285..3204542 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
HWS75_RS15270 3204529..3204972 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
HWS75_RS15275 3205052..3205714 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
HWS75_RS15280 3205810..3206001 + 192 WP_003909769.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
HWS75_RS15285 3206333..3208081 + 1749 WP_235733004.1 cytochrome c biogenesis protein DipZ -
HWS75_RS15290 3208177..3208758 + 582 WP_003414644.1 fasciclin domain-containing protein -
HWS75_RS15295 3208858..3209124 + 267 WP_031667416.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T166373 WP_003414624.1 NZ_CP058236:3204529-3204972 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T166373 NZ_CP074140:c6050321-6049980 [Serratia sp. JSRIV004]
ATGGATGCTATATTTGTTGAGTTAAGTATTTTTGAAGCGAAGCGTGCTGATTATCTTTCCGATGATGAATTCAAGACATT
CCAGCAGATGCTGCTGATTAATCCATTCTGCGGTGATGTTATCCAGCACACTGGCGGGTTAAGGAAGGTCAGATTTGCGG
ATCACCGTCGTGGAAAAGGTAAACGAGGTGGCTTGCGGGTGATCTATTATTGGTGGCTTGAAAAGTCTCACTTTTTGCTT
TTTGTCATTTACGACAAAGACAAAAAAGATGACCTTAGCCGCAACGAGCGCGAGATGCTGCGTAGGATGTTGGAAATTTT
GAAACAAGGGGGCACCTTATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT166373 WP_003414620.1 NZ_CP058236:3204285-3204542 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT166373 NZ_CP074140:c6049983-6049669 [Serratia sp. JSRIV004]
ATGAGCGAACTCAGCCTTTTTGAAGAACTATCCCAGGGAATGAAAGACTGGAGTGATTACAATGAGGGTAAAATCACGCT
TAAAACCCACGCCGTATCACTGAAAAAAAACATATCTATGTCACCAGACGAGTTAAAAGCAATACGTGAAAAACTGCGTC
TTTCACAAGCCGTTTTTGCGGATTACTTGCATACCGGTGTCACTACTTATCAAAACTGGGAACAGGGCAGAGCCAAACCC
AACAAACAGGCACTTCTTTTGATCCGTATGGTTGAAAAAGACCCCATGACGCTGGATACGTTAGCTGCCTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References