Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3198684..3199232 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag HWS75_RS15240 Protein ID WP_003414602.1
Coordinates 3198969..3199232 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag HWS75_RS15235 Protein ID WP_003414599.1
Coordinates 3198684..3198965 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS15210 3194307..3195164 - 858 WP_003899513.1 type I methionyl aminopeptidase -
HWS75_RS15215 3195206..3195790 - 585 WP_003414585.1 DUF1707 domain-containing protein -
HWS75_RS15220 3195894..3196142 + 249 WP_003913411.1 antitoxin VapB23 -
HWS75_RS15225 3196139..3196519 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
HWS75_RS15230 3196601..3198412 - 1812 WP_003414596.1 penicillin-binding protein -
HWS75_RS15235 3198684..3198965 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
HWS75_RS15240 3198969..3199232 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HWS75_RS15245 3199605..3200459 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
HWS75_RS15250 3200515..3201678 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
HWS75_RS15255 3201695..3202909 - 1215 WP_003414610.1 zinc metalloprotease Rip -
HWS75_RS15260 3202917..3204158 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T166372 WP_003414602.1 NZ_CP058236:3198969-3199232 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T166372 NZ_CP074140:5282227-5282508 [Serratia sp. JSRIV004]
ATGACTTATAAGCTCAAATTTGAAAAGCGCGCACTGAAGGAATGGGAAAAGCTAGGTTATCCCGTTCGGGAACAACTGAA
AAAGAAGCTGGCCGAGCGTTTAGAAAACCCGCATGTGCCGGCATCCCGCCTAAGTGGCCGCCCGAACCGTTACAAAATCA
AACTGCGCTCATCAGGCTATCGGTTGGTTTATGAAGTACGTGATAATGAAATTGTTCTATTGGTGATCGCCGTTGGAAAA
CGAGCTGGGGAGGAAGTCTATTTTGCTGCCGATAAGCGATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT166372 WP_003414599.1 NZ_CP058236:3198684-3198965 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT166372 NZ_CP074140:5281986-5282237 [Serratia sp. JSRIV004]
ATGGCCTTTCAAATTTTAACCACTATCGCTGCCAGCATCACCGACCTGAAAAAGAACCCGATGGGAACCGTTGCAGACGG
AGAAGGTGAAGCGGTTGCCATCCTGAATCGTAACGAACCGGCTTTCTACTGCGTGCCCCCTGAGCTGTATGCATACTATC
GGGAGCTTGCCGAAGATGCAGAATTAAACCGTATTGCAGATGAACGCATGGAAGATGCGGAGTTTGTGAGCGTAGATCTT
AATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References