Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 3155019..3156793 | Replicon | chromosome |
| Accession | NZ_CP058236 | ||
| Organism | Mycobacterium tuberculosis strain 060827 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | P71626 |
| Locus tag | HWS75_RS15025 | Protein ID | WP_003414409.1 |
| Coordinates | 3155019..3155903 (-) | Length | 295 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | P71625 |
| Locus tag | HWS75_RS15030 | Protein ID | WP_003414414.1 |
| Coordinates | 3155906..3156793 (-) | Length | 296 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWS75_RS15005 | 3150274..3150648 | - | 375 | WP_003414296.1 | type III-A CRISPR-associated protein Csm2 | - |
| HWS75_RS15010 | 3150645..3153083 | - | 2439 | WP_031667895.1 | type III-A CRISPR-associated protein Cas10/Csm1 | - |
| HWS75_RS15015 | 3153080..3153868 | - | 789 | WP_003917092.1 | CRISPR-associated endoribonuclease Cas6 | - |
| HWS75_RS15020 | 3154202..3154747 | - | 546 | WP_003904931.1 | DUF1802 family protein | - |
| HWS75_RS15025 | 3155019..3155903 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| HWS75_RS15030 | 3155906..3156793 | - | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| HWS75_RS15035 | 3157098..3157643 | - | 546 | WP_003899500.1 | DUF1802 family protein | - |
| HWS75_RS15040 | 3157640..3157909 | - | 270 | WP_003414489.1 | DUF2277 family protein | - |
| HWS75_RS15045 | 3157930..3158322 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | - |
| HWS75_RS15050 | 3158319..3158534 | - | 216 | WP_003414495.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| HWS75_RS15055 | 3158581..3159330 | + | 750 | WP_003414497.1 | enoyl-CoA hydratase | - |
| HWS75_RS15060 | 3159409..3160491 | - | 1083 | WP_003414499.1 | sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 295 a.a. Molecular weight: 33056.72 Da Isoelectric Point: 7.1520
>T166370 WP_003414409.1 NZ_CP058236:c3155903-3155019 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
Download Length: 885 bp
>T166370 NZ_CP074140:5098920-5099255 [Serratia sp. JSRIV004]
ATGAAGACCATGAACAAACTCCCCCACACCCCGTCCAATGCCAGTCCCGCCTTTCTCGAATACCAGCAACTGCTTGCCTG
GTTGCTGGCTCACTGTTACGGCCTGGAGCTCAATGACACGCCGTATCACGACGATCAGGCGATTACCCAACAGATTGAGT
ATGGCGTCACGGTACGCGAAACCGTCAACGAACTGGTGGAGAAATTTGACCTAGTACGTATTGACCGACCTGGATTCAGC
CTTATGGCACAAGATCCGACTTTGAGCGCCGGTGACATGCTCTGCGCCCGCAGCGCACGGGGATTACGCAGCCCGGTGAT
TCGCCGCCTGGCTTGA
ATGAAGACCATGAACAAACTCCCCCACACCCCGTCCAATGCCAGTCCCGCCTTTCTCGAATACCAGCAACTGCTTGCCTG
GTTGCTGGCTCACTGTTACGGCCTGGAGCTCAATGACACGCCGTATCACGACGATCAGGCGATTACCCAACAGATTGAGT
ATGGCGTCACGGTACGCGAAACCGTCAACGAACTGGTGGAGAAATTTGACCTAGTACGTATTGACCGACCTGGATTCAGC
CTTATGGCACAAGATCCGACTTTGAGCGCCGGTGACATGCTCTGCGCCCGCAGCGCACGGGGATTACGCAGCCCGGTGAT
TCGCCGCCTGGCTTGA
Antitoxin
Download Length: 296 a.a. Molecular weight: 32315.19 Da Isoelectric Point: 9.4723
>AT166370 WP_003414414.1 NZ_CP058236:c3156793-3155906 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
Download Length: 888 bp
>AT166370 NZ_CP074140:5099333-5099710 [Serratia sp. JSRIV004]
ATGAAAGAACCCGTTCTCAATACCGATAATAACGCAGCCCCACTCACCGACGAAGACAACATACCGTCACCCGTCTGGGG
CTTGCACTGTGCCATTACTCCCCGTCTGGGAGCAAGGCTGGTACAAAAAGGTAACCGCCTGCATTTTCTACCCGACCGCG
CCGGCTTTGTCGGTATGTTCTCCCCTGATGCGCTTAAAACGCTGGATCGCGCCTTCCCAGTGCTGATTAAACTGTTGGAA
GCCTGTCTGCGCTCGGGTGAGCTCGACCAGCGCCGCCAGCACTGCGTTACGGTGCAGCACGCTGGTTTTACCTGCGAAGC
CGATACCTTGGGTAGCTTTGGCCACGTCTATCTGGCGGTCTATCAGACACCGACATAA
ATGAAAGAACCCGTTCTCAATACCGATAATAACGCAGCCCCACTCACCGACGAAGACAACATACCGTCACCCGTCTGGGG
CTTGCACTGTGCCATTACTCCCCGTCTGGGAGCAAGGCTGGTACAAAAAGGTAACCGCCTGCATTTTCTACCCGACCGCG
CCGGCTTTGTCGGTATGTTCTCCCCTGATGCGCTTAAAACGCTGGATCGCGCCTTCCCAGTGCTGATTAAACTGTTGGAA
GCCTGTCTGCGCTCGGGTGAGCTCGACCAGCGCCGCCAGCACTGCGTTACGGTGCAGCACGCTGGTTTTACCTGCGAAGC
CGATACCTTGGGTAGCTTTGGCCACGTCTATCTGGCGGTCTATCAGACACCGACATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|