Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3092613..3093300 | Replicon | chromosome |
| Accession | NZ_CP058236 | ||
| Organism | Mycobacterium tuberculosis strain 060827 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TF65 |
| Locus tag | HWS75_RS14680 | Protein ID | WP_003414064.1 |
| Coordinates | 3092905..3093300 (-) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | HWS75_RS14675 | Protein ID | WP_003414061.1 |
| Coordinates | 3092613..3092879 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWS75_RS14645 | 3088252..3089154 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| HWS75_RS14650 | 3089223..3089975 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
| HWS75_RS14660 | 3090219..3090494 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| HWS75_RS14665 | 3090491..3092113 | - | 1623 | WP_003909739.1 | class I SAM-dependent DNA methyltransferase | - |
| HWS75_RS14670 | 3092200..3092616 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | - |
| HWS75_RS14675 | 3092613..3092879 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| HWS75_RS14680 | 3092905..3093300 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| HWS75_RS14685 | 3093297..3093566 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| HWS75_RS14690 | 3093576..3094670 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| HWS75_RS14695 | 3094667..3095086 | - | 420 | WP_003414070.1 | winged helix-turn-helix domain-containing protein | - |
| HWS75_RS14700 | 3095085..3095159 | + | 75 | Protein_2901 | hypothetical protein | - |
| HWS75_RS14705 | 3095160..3095639 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| HWS75_RS14710 | 3095710..3096510 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
| HWS75_RS14715 | 3096666..3097403 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14340.04 Da Isoelectric Point: 4.7145
>T166368 WP_003414064.1 NZ_CP058236:c3093300-3092905 [Mycobacterium tuberculosis]
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT
Download Length: 396 bp
>T166368 NZ_CP074140:4534283-4534666 [Serratia sp. JSRIV004]
ATGCAAACTGTATTGGTTACCTCGAAACGGGCGGCACCGTCTTGCCCATCACCCATCGCGATCTGGCAGGTATTGATGAC
CCATCTATTGCAACAACACTATGGTCTGACACTGGAAGATACCGCCTTTAGTCACGAGGGTGTGATCCAAGAGCATCTTA
ATGCAGGGATTTCCCTGGCGGATGCGCTGAATTTTATCGTGGAAAAATATGAACTGGTCCGTATTGATCGCACCGGTTTT
AGTATCCGTGAACAATCACCGTTTATTACGCCTATCGATATTCTCCGGGCCCGACAGGCTACCGGTCTGATGAAACGCCG
AGGTTACAAGGCCATCACTCATATCACCAACGGTAAAAACCAACGACAGGGGGCACATCCGTGA
ATGCAAACTGTATTGGTTACCTCGAAACGGGCGGCACCGTCTTGCCCATCACCCATCGCGATCTGGCAGGTATTGATGAC
CCATCTATTGCAACAACACTATGGTCTGACACTGGAAGATACCGCCTTTAGTCACGAGGGTGTGATCCAAGAGCATCTTA
ATGCAGGGATTTCCCTGGCGGATGCGCTGAATTTTATCGTGGAAAAATATGAACTGGTCCGTATTGATCGCACCGGTTTT
AGTATCCGTGAACAATCACCGTTTATTACGCCTATCGATATTCTCCGGGCCCGACAGGCTACCGGTCTGATGAAACGCCG
AGGTTACAAGGCCATCACTCATATCACCAACGGTAAAAACCAACGACAGGGGGCACATCCGTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT166368 WP_003414061.1 NZ_CP058236:c3092879-3092613 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT166368 NZ_CP074140:4533854-4534222 [Serratia sp. JSRIV004]
ATGACCGATAGTAAACCTGATACCCCCTCCCAGGGGGCTGATATCACCCCACCAGCCTGGGGACTAAAACGTATCATCAC
CCCTCAGGTTGGTGCTCGCCTGGTACAGCAAGGCCACCAACTGCATTACCTGGCAGACCGTGCCGATATCGTGGGGAAGT
TCAGTGATGCCGAGTTGCGTCATCTCGACCAGGTATTCCCGTTATGGCTTCAGCAGTTGGAGTCGATGCTGATGTCTGCT
GAACTCAATCCCCGACAACAACACTGCGTCACACTCCATGCGAGCGGACTGACACTCGAAGCCGATACGTTGGGCTCCTG
CGGGTACGTGTATATATCTATCTATCCAACATCAGCTACAACTGCATAA
ATGACCGATAGTAAACCTGATACCCCCTCCCAGGGGGCTGATATCACCCCACCAGCCTGGGGACTAAAACGTATCATCAC
CCCTCAGGTTGGTGCTCGCCTGGTACAGCAAGGCCACCAACTGCATTACCTGGCAGACCGTGCCGATATCGTGGGGAAGT
TCAGTGATGCCGAGTTGCGTCATCTCGACCAGGTATTCCCGTTATGGCTTCAGCAGTTGGAGTCGATGCTGATGTCTGCT
GAACTCAATCCCCGACAACAACACTGCGTCACACTCCATGCGAGCGGACTGACACTCGAAGCCGATACGTTGGGCTCCTG
CGGGTACGTGTATATATCTATCTATCCAACATCAGCTACAACTGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|