Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2952715..2953429 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag HWS75_RS13845 Protein ID WP_003413460.1
Coordinates 2952989..2953429 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag HWS75_RS13840 Protein ID WP_003413456.1
Coordinates 2952715..2953002 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS13805 2948137..2948382 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HWS75_RS13810 2948379..2948783 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
HWS75_RS13815 2949000..2949620 + 621 WP_003909700.1 DUF4178 domain-containing protein -
HWS75_RS13820 2949631..2950125 + 495 WP_003909701.1 DUF2617 family protein -
HWS75_RS13825 2950122..2950553 + 432 WP_003413445.1 DUF4247 domain-containing protein -
HWS75_RS13830 2950578..2951036 + 459 WP_003413451.1 DUF350 domain-containing protein -
HWS75_RS13835 2951033..2952604 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
HWS75_RS13840 2952715..2953002 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
HWS75_RS13845 2952989..2953429 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
HWS75_RS13850 2953450..2954205 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
HWS75_RS13855 2954338..2954934 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
HWS75_RS13860 2954942..2955787 - 846 WP_235732999.1 acyl-CoA thioesterase II -
HWS75_RS13865 2955816..2956715 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
HWS75_RS13870 2956843..2957517 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T166365 WP_003413460.1 NZ_CP058236:2952989-2953429 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T166365 NZ_CP074140:c3557436-3557341 [Serratia sp. JSRIV004]
AACAAACCTTGCATAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCCTTTCCCTAGACCGAGTATAGGAATCG
TACTCGGTCTTTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT166365 WP_003413456.1 NZ_CP058236:2952715-2953002 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT166365 NZ_CP074140:3557339-3557427 [Serratia sp. JSRIV004]
ATAAAAAAAGACCGAGTACGATTCCTATACTCGGTCTAGGGAAAGGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTTATGCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References