Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2830123..2830775 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag HWS75_RS13275 Protein ID WP_003412752.1
Coordinates 2830350..2830775 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7U8TSR0
Locus tag HWS75_RS13270 Protein ID WP_003909675.1
Coordinates 2830123..2830344 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS13255 2828363..2828569 - 207 WP_003899347.1 hypothetical protein -
HWS75_RS13260 2828705..2829328 + 624 WP_003900858.1 TIGR00725 family protein -
HWS75_RS13265 2829318..2830070 + 753 WP_235732994.1 hypothetical protein -
HWS75_RS13270 2830123..2830344 + 222 WP_003909675.1 hypothetical protein Antitoxin
HWS75_RS13275 2830350..2830775 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
HWS75_RS13280 2830798..2831979 - 1182 WP_235732995.1 dihydrolipoamide acetyltransferase family protein -
HWS75_RS13285 2831976..2833022 - 1047 WP_003909676.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
HWS75_RS13290 2833033..2834136 - 1104 WP_003909677.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
HWS75_RS13295 2834395..2835216 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
HWS75_RS13300 2835213..2835770 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T166360 WP_003412752.1 NZ_CP058236:2830350-2830775 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T166360 NZ_CP074140:c719734-719399 [Serratia sp. JSRIV004]
ATGAAGACCATCAACAAACTCCCCCACACCCCGACCCATGCCAATCCCACCTTTATCGAATACCAGCAACTGTTGGCCTG
GTTGCTGGGCCATTGCTATGGCCTGGAACTTAACGATACGCCCTATCACGACGACCAGGCGATTGCTCAACAGATTGAAC
ATGGCATTACCGTAAGGGAGACCGTCAACGAACTGGTGGAGAAATTTGATCTGGTACGCATTGATCGCCCCGGTTTCAGC
CTGATGGCACAAGACCCAACCCTAAGCGGGGGCGATCTCCTACGGGCCCGCAGTGCGCTAGGTTTGCGAAGCCCAGCCAT
TCGCCGCCTTGCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7863.99 Da        Isoelectric Point: 5.0323

>AT166360 WP_003909675.1 NZ_CP058236:2830123-2830344 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDKD

Download         Length: 222 bp

>AT166360 NZ_CP074140:c719320-718952 [Serratia sp. JSRIV004]
ATGAAAGATAGCGATACCGATAACCACGAAGACAGCACACCGTCCCCCATCTGGGGCCTGCACTGTGCTATCACGCCAAG
ATTAGGTGCCAGACTGGTGCAACAGGGCAATCGTCTGCATTTTCTGGTTGACCGCGCCGGTCTGGTTGGCACCTTTTCAC
CCAACGACCTCAAGGGGCTGAATAGCGCCTTCCCCGTGCTGATTGAACAGTTGGAAACCTGTCTGCGCTCGGGTGAACTC
GACCAGCGCCGCCAGCACTGCGTCACGGTCCAGCACGCCGGTTTTACCTGCCAGGCTGATACGTTGGGCAGTTTTGGGCA
TGTCTATATCGCTGTTTATCAGACAGCACAGCACACGAGCGGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U8TSR0

References