Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2430746..2431275 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag HWS75_RS11395 Protein ID WP_003411124.1
Coordinates 2430746..2431063 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag HWS75_RS11400 Protein ID WP_003411127.1
Coordinates 2431060..2431275 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS11365 2425767..2426843 + 1077 WP_003411110.1 hypothetical protein -
HWS75_RS11370 2426840..2427121 + 282 WP_003411112.1 DUF5703 family protein -
HWS75_RS11375 2427157..2428230 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
HWS75_RS11380 2428235..2428765 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
HWS75_RS11385 2428813..2430159 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
HWS75_RS11395 2430746..2431063 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HWS75_RS11400 2431060..2431275 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
HWS75_RS11405 2431530..2432588 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
HWS75_RS11410 2432718..2433074 - 357 WP_003411130.1 hypothetical protein -
HWS75_RS11415 2433169..2433951 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
HWS75_RS11420 2434219..2434509 - 291 WP_003900476.1 YggT family protein -
HWS75_RS11425 2434671..2435327 - 657 WP_003411133.1 cell division protein SepF -
HWS75_RS11430 2435393..2436169 - 777 WP_235733109.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T166359 WP_003411124.1 NZ_CP058236:c2431063-2430746 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T166359 NZ_CP074140:684545-684820 [Serratia sp. JSRIV004]
ATGCGCATCGAATGGGACGACGTTGCGTTGCAAGATCGGGAACGCATTTTTGAATTTCTTTATCCACTCAATTCATTGGC
CGCGGAACAAGTTGATGATGAGATTGAACTTGCCGTTGAGTCTCTGCTAGAAAACCCAGAAATGGGCAGGCCTTGGTATG
GGGAAGCTCGCAAACTGGTGATCAGTAAAGCCTCCCTATTGCTGATTTATGTCATTTTGGATGAGGTGATAAAGGTTTTA
GCCGTCGCCCATCAGCGTGAAAAATTCCCCAATTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT166359 WP_003411127.1 NZ_CP058236:c2431275-2431060 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT166359 NZ_CP074140:684249-684536 [Serratia sp. JSRIV004]
ATGGAAAGCCGTATCCAGTTTCGCATTGAAAATGAAACTAAACTGTTGGCACAGAAAGCTGCTGAAGCGAAAGGGACGAC
CTTAAGTGAAGCCTGTCGGCGTTTAGCGCAACAAATGGCGGACGATCAACGTGCTGCTGAAGAACACGAAAACTGGTTGA
AAGATAAGGTTGATGCAGCCTTTGCCCGTTTGCATGAAGGAGAGGCTGTTTATCTTACCCAGCGGCAAGCTGAGGAGAGA
ATGAGCGACTTTAAAGCCAAAGTCAGGGCGAAATACGCAACCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References