Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2392584..2393279 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag HWS75_RS11185 Protein ID WP_003410811.1
Coordinates 2392584..2393018 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag HWS75_RS11190 Protein ID WP_003410814.1
Coordinates 2393025..2393279 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS11175 2388738..2391779 + 3042 WP_031667498.1 DEAD/DEAH box helicase -
HWS75_RS11180 2391772..2392605 + 834 WP_003899172.1 SWIM zinc finger family protein -
HWS75_RS11185 2392584..2393018 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
HWS75_RS11190 2393025..2393279 - 255 WP_003410814.1 antitoxin Antitoxin
HWS75_RS11195 2393295..2393552 - 258 WP_003410816.1 hypothetical protein -
HWS75_RS11200 2393885..2395146 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
HWS75_RS11205 2395857..2396153 + 297 WP_003410820.1 PE family protein -
HWS75_RS11210 2396209..2396940 + 732 WP_003900467.1 PPE family protein -
HWS75_RS11215 2397480..2398226 - 747 WP_003901330.1 proteasome subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T166358 WP_003410811.1 NZ_CP058236:c2393018-2392584 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T166358 NZ_CP074140:556583-556861 [Serratia sp. JSRIV004]
ATGGAAATTGTTTGGACGCAATTAGCCAGCGAGGACAGGCGCAAAATCCGGGAGTACATTGCTGAAAACAACCTGCGTGC
TGCCATTGAGCTAGACGAGCGGATCGGCTCAATGGCAAACAGCCTGGCCGAGCATCCGTTGAAGGGGCGTGAGGGCCGTG
TTAAAGAAACAAGAGAACTGGTTATCCATCCTCACTTCATTGAGGTTTATCGTGTCGTCAATGAATGGGAGAGGATTGAG
ATCATCCGCGTACTTCATACCGCGCAGCAATGGCCTTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT166358 WP_003410814.1 NZ_CP058236:c2393279-2393025 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT166358 NZ_CP074140:556314-556583 [Serratia sp. JSRIV004]
ATGACACAGACAACTCTGAATTTACGCATCGACACCGAACTGAAAACTGACTTTTTGGAGGCAGCAAAAGCGATGGATCG
TAATGGTTCGCAGCTCATTCGTGACTTCATGCGTGAGACGGTTCAGCGCCAACATGATATATGGTTCCGTGATCAGGTAC
AGGCTGGAATTGCCCAGGCAAATCGTGGCGAAGTTCTTTCAGGAGAGTCCGTCGAAGCCTCTGCAGTAGCCTGGCGTGAG
GCGGCAGCGAAGAAACTGGCGGGTAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References