Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2257830..2258416 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag HWS75_RS10595 Protein ID WP_003410010.1
Coordinates 2257830..2258174 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag HWS75_RS10600 Protein ID WP_003410014.1
Coordinates 2258168..2258416 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS10560 2253535..2254134 + 600 WP_003409989.1 L-lysine exporter -
HWS75_RS10565 2254550..2254978 + 429 WP_003409992.1 cellulose-binding protein -
HWS75_RS10570 2255204..2255743 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
HWS75_RS10575 2256263..2256823 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
HWS75_RS10580 2256820..2257161 - 342 WP_003410003.1 DUF2384 domain-containing protein -
HWS75_RS10585 2257247..2257504 + 258 WP_003410006.1 hypothetical protein -
HWS75_RS10590 2257405..2257740 - 336 WP_003410009.1 dehydrogenase -
HWS75_RS10595 2257830..2258174 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
HWS75_RS10600 2258168..2258416 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
HWS75_RS10605 2258516..2259328 - 813 Protein_2095 cation transporter ATPase CptG -
HWS75_RS10610 2259279..2260169 + 891 WP_078441325.1 universal stress protein -
HWS75_RS10615 2260371..2263088 + 2718 WP_003410027.1 cation-transporting P-type ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T166354 WP_003410010.1 NZ_CP058236:c2258174-2257830 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

>T166354 NZ_CP074138:c56841-56509 [Serratia sp. JSRIV006]
ATGGTTAAGGGTTACGTTCCTGACGCCGGTGATATTGTCTGGCTAGAGTTTGATCCCCAGGCGGGGCATGAACAAGCGGG
CCATCGCCCTGCATTAGTGCTAAGCCCAGCCGTATACAACGGGCGGATTGGGTTAATGCTGTGCTGCCCGATGACGACCA
AAATTAAAGGGTACCCTTTTGAAGTCATTGTCCCTGGTGAACGTGAGAGTGCAGTCCTTGCAGATCAAGTTAAGAGCCTG
GATTGGAAAGAACGTAATGCCATAAAAAAGGGAAAGGTGCCTGCGTCGGTACTATCAGATGTACGTGCAAAGGCAAAAGC
CTTAATTGGGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT166354 WP_003410014.1 NZ_CP058236:c2258416-2258168 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp

>AT166354 NZ_CP074138:c57086-56841 [Serratia sp. JSRIV006]
ATGTCTCAAGTTGTGGTAAAAAAATGGGGCAACAGCCCGTCAGTCAGGCTTCCTGTAGCCATCATGAAAGCGGCATCGCT
CAACGTGGATGATACTGTTGAGGTCAGCGTCGAAGAAGGACGTATAGTCATTGTACCGGTGCGGGCAAAGGTCTATTCGC
TTGACGGCCTGTTGGCAGGCGTGACGGACGAGAACATTCACCAGGCCGTTTCGTTTGGTGAGCCTGTTGGCAATGAGGCA
CTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
PDB 7WJ0
PDB 7WNR
AlphaFold DB A0A7U4FAW9

References