Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2256263..2257161 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag HWS75_RS10575 Protein ID WP_003410001.1
Coordinates 2256263..2256823 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag HWS75_RS10580 Protein ID WP_003410003.1
Coordinates 2256820..2257161 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS10545 2251432..2252085 - 654 WP_003409976.1 cutinase Cfp21 -
HWS75_RS10550 2252200..2252430 + 231 WP_003409980.1 DUF167 domain-containing protein -
HWS75_RS10555 2252515..2253426 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
HWS75_RS10560 2253535..2254134 + 600 WP_003409989.1 L-lysine exporter -
HWS75_RS10565 2254550..2254978 + 429 WP_003409992.1 cellulose-binding protein -
HWS75_RS10570 2255204..2255743 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
HWS75_RS10575 2256263..2256823 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
HWS75_RS10580 2256820..2257161 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
HWS75_RS10585 2257247..2257504 + 258 WP_003410006.1 hypothetical protein -
HWS75_RS10590 2257405..2257740 - 336 WP_003410009.1 dehydrogenase -
HWS75_RS10595 2257830..2258174 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
HWS75_RS10600 2258168..2258416 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
HWS75_RS10605 2258516..2259328 - 813 Protein_2095 cation transporter ATPase CptG -
HWS75_RS10610 2259279..2260169 + 891 WP_078441325.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T166353 WP_003410001.1 NZ_CP058236:c2256823-2256263 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T166353 NZ_CP074137:c5718446-5718105 [Serratia sp. JSRIV006]
ATGGATGCTATATTTGTTGAGTTAAGTATTTTTGAAGCGAAGCGTGCTGATTATCTTTCCGATGATGAATTCAAGACATT
CCAGCAGATGCTGCTGATTAATCCATTCTGCGGTGATGTTATCCAGCACACTGGCGGGTTAAGGAAGGTCAGATTTGCGG
ATCACCGTCGTGGAAAAGGTAAACGAGGTGGCTTGCGGGTGATCTATTATTGGTGGCTTGAAAAGTCTCACTTTTTGCTT
TTTGTCATTTACGACAAAGACAAAAAAGATGACCTTAGCCGCAACGAGCGCGAGATGCTGCGTAGGATGTTGGAAATTTT
GAAACAAGGGGGCACCTTATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT166353 WP_003410003.1 NZ_CP058236:c2257161-2256820 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT166353 NZ_CP074137:c5718108-5717794 [Serratia sp. JSRIV006]
ATGAGCGAACTCAGCCTTTTTGAAGAACTATCCCAGGGAATGAAAGACTGGAGTGATTACAATGAGGGTAAAATCACGCT
TAAAACCCACGCCGTATCACTGAAAAAAAACATATCTATGTCACCAGACGAGTTAAAAGCAATACGTGAAAAACTGCGTC
TTTCACAAGCCGTTTTTGCGGATTACTTGCATACCGGTGTCACTACTTATCAAAACTGGGAACAGGGCAGAGCCAAACCC
AACAAACAGGCACTTCTTTTGATCCGTATGGTTGAAAAAGACCCCATGACGCTGGATACGTTAGCTGCCTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References