Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2248937..2249625 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag HWS75_RS10530 Protein ID WP_003409958.1
Coordinates 2248937..2249356 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag HWS75_RS10535 Protein ID WP_003409968.1
Coordinates 2249365..2249625 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS10505 2244287..2244565 - 279 WP_003907828.1 hypothetical protein -
HWS75_RS10510 2244695..2245342 - 648 WP_003909553.1 PE family protein -
HWS75_RS10515 2246122..2246721 + 600 WP_234776458.1 hypothetical protein -
HWS75_RS10520 2246867..2247553 - 687 WP_003909555.1 immunoprotective protein Mpt64 -
HWS75_RS10525 2247744..2248712 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
HWS75_RS10530 2248937..2249356 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
HWS75_RS10535 2249365..2249625 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HWS75_RS10540 2249768..2251444 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
HWS75_RS10545 2251432..2252085 - 654 WP_003409976.1 cutinase Cfp21 -
HWS75_RS10550 2252200..2252430 + 231 WP_003409980.1 DUF167 domain-containing protein -
HWS75_RS10555 2252515..2253426 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
HWS75_RS10560 2253535..2254134 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T166352 WP_003409958.1 NZ_CP058236:c2249356-2248937 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T166352 NZ_CP074137:5012152-5012433 [Serratia sp. JSRIV006]
ATGACTTATAAGCTCAAATTTGAAAAGCGCGCACTGAAGGAATGGGAAAAGCTGGGTTATCCCGTTCGGGAACAACTGAA
AAAGAAGCTGGCCGAGCGTTTAGAAAACCCGCATGTGCCGGCATCCCGCCTAAGTGGCCGCCCGAACCGTTACAAAATCA
AACTGCGCTCATCAGGCTATCGGTTGGTTTATGAAGTACGTGATAATGAAATTGTTCTATTGGTGATCGCCGTTGGAAAA
CGAGCTGGGGAGGAAGTCTATTTTGCTGCCGATAAGCGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT166352 WP_003409968.1 NZ_CP058236:c2249625-2249365 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT166352 NZ_CP074137:5011911-5012162 [Serratia sp. JSRIV006]
ATGGCCTTTCAAATTTTAACCACTATCGCTGCCAGCATCACCGACCTGAAAAAGAACCCGATGGGAACCGTTGCAGACGG
AGAAGGTGAAGCGGTTGCCATCCTGAATCGTAACGAACCGGCTTTCTACTGCGTGCCCCCTGAGCTGTATGCATACTATC
GGGAGCTTGCCGAAGATGCAGAATTAAACCGTATTGCAGATGAACGCATGGAAGATGCGGAGTTTGTGAGCGTAGATCTT
AATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References