Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1983185..1983645 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag HWS75_RS09285 Protein ID WP_003898996.1
Coordinates 1983397..1983645 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag HWS75_RS09280 Protein ID WP_003408528.1
Coordinates 1983185..1983397 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS09265 1979663..1980850 - 1188 WP_003898992.1 nitrate transporter NarK -
HWS75_RS09270 1981137..1981421 + 285 WP_003408522.1 DUF1876 domain-containing protein -
HWS75_RS09275 1981435..1983117 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
HWS75_RS09280 1983185..1983397 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HWS75_RS09285 1983397..1983645 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
HWS75_RS09290 1983653..1984391 + 739 Protein_1833 hypothetical protein -
HWS75_RS09295 1984485..1986185 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
HWS75_RS09300 1986470..1986871 - 402 WP_003408538.1 hypothetical protein -
HWS75_RS09305 1986861..1987472 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T166348 WP_003898996.1 NZ_CP058236:1983397-1983645 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T166348 NZ_CP074137:c4391361-4390945 [Serratia sp. JSRIV006]
ATGAACAAAACCTACATGCTGGATACCAATATTTGCTCCTTTATCATGCGTGAGCAACCAGAGGCCGTGATCAGACGCCT
GGAGCAGGCAGTGATGCGCAATCACCGTATCGTGGTGTCGGCTATTACCTACGCCGAGATGTGTTTCGGGACTATTGGTA
AAAAGGCCTCACCGCGCCACGCCCGGTTGGTTGAAGCGTTCTGTAGCCGTCTTGATGCGGTGCTGGCTTGGGATCGGGCT
GCGGTTGATGCGACAACAAACATTAAGGCTACGCTTGCTGCGGCTGGCACACCTATTGGCCCCAATGATACCGCCATCGC
TGGGCATGCCATTGCGGCCGGTGCGATTCTGGTAACCAATAACACGCGGGAGTTTGAGCGGGTAACAGATCTGATACTGG
AGGATTGGGCAAAATAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT166348 WP_003408528.1 NZ_CP058236:1983185-1983397 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT166348 NZ_CP074137:c4391588-4391358 [Serratia sp. JSRIV006]
ATGAGAATTGTATCGGTATTTAAAAACGGCAATAACCGTGCTATCCGTTTGCCCCGAGATATGGACTTTGAAGGTGTCAG
TGAACTGGAAATTACCCGTGAAGGCGATAGTATCATTCTGCGCCCGGTTCGCCCCAGCTGGGGCTCATTCCTGCAGGAAG
AAAAGGCCGACGCGGACTTTATGACAGAGCGCGAGGAGATTGTCAGCGACGAGGGACGTTTTGAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References