Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1962510..1963123 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag HWS75_RS09175 Protein ID WP_003408465.1
Coordinates 1962510..1962899 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag HWS75_RS09180 Protein ID WP_003408469.1
Coordinates 1962896..1963123 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS09140 1958139..1959053 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
HWS75_RS09145 1959056..1959886 + 831 WP_003408448.1 cyclase family protein -
HWS75_RS09150 1959886..1960236 + 351 WP_003898986.1 cupin domain-containing protein -
HWS75_RS09155 1960289..1961107 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
HWS75_RS09160 1961121..1961900 + 780 WP_128883641.1 IclR family transcriptional regulator -
HWS75_RS09170 1962331..1962462 + 132 Protein_1809 IS3 family transposase -
HWS75_RS09175 1962510..1962899 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
HWS75_RS09180 1962896..1963123 - 228 WP_003408469.1 antitoxin Antitoxin
HWS75_RS09185 1963341..1964825 + 1485 WP_003408473.1 biotin carboxylase -
HWS75_RS09190 1964822..1966069 + 1248 WP_235733098.1 serine hydrolase -
HWS75_RS09195 1966112..1966531 - 420 WP_003408483.1 hypothetical protein -
HWS75_RS09200 1966521..1967231 - 711 WP_003909499.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T166347 WP_003408465.1 NZ_CP058236:c1962899-1962510 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T166347 NZ_CP074137:c4190558-4190169 [Serratia sp. JSRIV006]
ATGTATATGTTCGACACTAACACGGTGAGCCAGCTTTTTCGTCAACATCCCCGGCTGCTTGCGGCTATGGGCCGGGTACC
GCCATCGTCGGTGTGTATTTCCAGCATAACCCAGGCGGAACTGCTTTATGGTGTCGCCAAGCGGCAGAACAAGGCGCTAA
AACAGACGGTGATGATGTTCCTGGACGCCGTCACCGTTTACTCCTGGGACTCTGCGGCGGCGCATTGCTATGGTGTCATG
CGCGCAAGTATGGAAAAACAAGGCAGACCGATGGGGGCGTTGGATCAGCTTATTGCCGCACATGCGGTAAGCCGTGGCGC
AACCATAGTGACCAGCGATCGGGCTTTCACTATGGTCGCGGAGCTTGAGGTGGAAGACTGGACGCTGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT166347 WP_003408469.1 NZ_CP058236:c1963123-1962896 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT166347 NZ_CP074137:c4190825-4190562 [Serratia sp. JSRIV006]
ATGGAAAGAGTCGCCAAGCTTTTTAAAAACGGTAGAAATCAGGCGGTGAGATTGCCAGTGGAATTCGAATTCGATGTCGA
TCAGGTTTATATTCGCCGGGATGAACAGGGTAACGTTATCTTGTCGAAGCATCCAATGAAATTGGACTCCTGGCAACCGC
TACTGACCATGCTGCAAAACGTGGCGGTTCCTGCTGACTTCCTGACTGCTGACGATCGCCAGCAAGGGGTAGCAGAACGG
GATCCGTTCAAGGAGGAACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References