Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1698367..1698983 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag HWS75_RS07985 Protein ID WP_003407593.1
Coordinates 1698666..1698983 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag HWS75_RS07980 Protein ID WP_003900349.1
Coordinates 1698367..1698669 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS07970 1694253..1696100 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
HWS75_RS07975 1696101..1698353 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
HWS75_RS07980 1698367..1698669 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
HWS75_RS07985 1698666..1698983 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
HWS75_RS07990 1698980..1699984 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
HWS75_RS07995 1700037..1701326 + 1290 WP_003407599.1 serine hydrolase domain-containing protein -
HWS75_RS08000 1701399..1702016 - 618 WP_003407606.1 class I SAM-dependent methyltransferase -
HWS75_RS08005 1702230..1702442 - 213 WP_003898900.1 dodecin family protein -
HWS75_RS08010 1702503..1702901 + 399 WP_003900351.1 hypothetical protein -
HWS75_RS08015 1702946..1703974 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T166345 WP_003407593.1 NZ_CP058236:1698666-1698983 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T166345 NZ_CP074137:c3326347-3326252 [Serratia sp. JSRIV006]
AACAAACCTTGCATAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCCTTTCCCTAGACCGAGTATAGGAATCG
TACTCGGTCTTTTTTT

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT166345 WP_003900349.1 NZ_CP058236:1698367-1698669 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT166345 NZ_CP074137:3326250-3326338 [Serratia sp. JSRIV006]
ATAAAAAAAGACCGAGTACGATTCCTATACTCGGTCTAGGGAAAGGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTTATGCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References