Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1585870..1586525 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FAR1
Locus tag HWS75_RS07485 Protein ID WP_003407268.1
Coordinates 1585870..1586271 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag HWS75_RS07490 Protein ID WP_003407272.1
Coordinates 1586268..1586525 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS07470 1581342..1582727 - 1386 WP_003407260.1 cytochrome P450 -
HWS75_RS07475 1582805..1583839 + 1035 WP_003407264.1 AraC family transcriptional regulator -
HWS75_RS07480 1583885..1585615 - 1731 Protein_1474 PE family protein -
HWS75_RS07485 1585870..1586271 - 402 WP_003407268.1 type II toxin-antitoxin system VapC family toxin Toxin
HWS75_RS07490 1586268..1586525 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
HWS75_RS07495 1586608..1587567 - 960 WP_003407276.1 alpha/beta hydrolase -
HWS75_RS07500 1587592..1588554 - 963 WP_003407279.1 alpha/beta hydrolase -
HWS75_RS07505 1588553..1589290 + 738 WP_031647000.1 lysoplasmalogenase -
HWS75_RS07510 1589371..1591338 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14894.39 Da        Isoelectric Point: 11.6897

>T166344 WP_003407268.1 NZ_CP058236:c1586271-1585870 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQGLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T166344 NZ_CP074137:c1680052-1679570 [Serratia sp. JSRIV006]
ATGGAAATAATCATTACCGCGCCGGAACTGCTGACAGAAGAGCATATTCTCCAACCATTCGACTGCGGAAATGAGGTGTT
GAGCGACTGGTTACGCCGTCGAGCCATGAGAAACCAACTCCTGAATGCCTCCCGCACTTTCGTTATTTGTCTGGAAGGCA
CCAAGCGTGTTGTGGGTTATTACTCCATTGCAACCGGTTCCGTCAGTCACGCCGATTTAGGCCGTAGCCTGCGCCAAAAC
ATGCCAGATCCTGTTCCCATCGTCCTGCTGGGACGTCTGGCCGTTGATGTATGTACCCAAGGCCATCGTTTTGGCAAGTG
GCTGCTTAATGATGCTGTAAGGCGTGTTGCCAATCTGGCAGACCAAGTGGGTATTAAAGCCATCATGGTGCACGCGATAG
ATGATCAAGCGAGAGCATTCTATGAGTACTTCGGCTTCGTCCAGTCTCCCATCGCTGCAAACACACTCTTCTACAAGATT
TGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT166344 WP_003407272.1 NZ_CP058236:c1586525-1586268 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT166344 NZ_CP074137:c1680327-1680043 [Serratia sp. JSRIV006]
ATGCAGAAAACCGTTCGTAAACCGACTCGTGACAAACAGATTAACGTCCGGGCGACCGAAGAAGAGCGTGCAGTCATCGA
CTATGCTGCGAGTCTGGTCAATAAGAACCGGACCGACTTCATCATTGAGAAGGCGGTTCATGAAGCACAGAACATCATCC
TGGATCAGCGGGTATTCGTGCTTGATGATGCGCGCTATCAGGCATTCATTGAACAGCTTGAAGCTCCTGTGCAAAACGTC
GAAGGGCGCAAGCGCTTAATGGATGTGAAGCCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FAR1

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References