Detailed information of TA system TA166342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1394403..1394962
• Replicon: chromosome
• Accession: NZ_CP058236
• Organism: Mycobacterium tuberculosis strain 060827

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: HWS75_RS06655
• Protein ID: WP_003898789.1
• Coordinates: 1394403..1394696 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: HWS75_RS06660
• Protein ID: WP_003406322.1
• Coordinates: 1394693..1394962 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HWS75_RS06630	1389998..1390258	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
HWS75_RS06635	1390255..1390686	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
HWS75_RS06640	1390709..1392395	-	1687	Protein_1312	PE family protein	-
HWS75_RS06645	1392575..1393435	+	861	WP_003900301.1	glycine betaine ABC transporter substrate-binding protein	-
HWS75_RS06650	1393516..1394346	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
HWS75_RS06655	1394403..1394696	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
HWS75_RS06660	1394693..1394962	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HWS75_RS06665	1395131..1398826	-	3696	WP_003406323.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
HWS75_RS06670	1398968..1399756	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T166342 WP_003898789.1 NZ_CP058236:c1394696-1394403 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T166342 NZ_CP074137:c1389391-1389188 [Serratia sp. JSRIV006]
ATGACAAAAATTGACTATCTGATGCGTTTGCGTAAATGCACCACGATTGAAACCCTTGAGCGCGTGATCGAGAAAAATAA
GTACGAACTTTCTGACGATGAGCTAGAGCTGTTCTACTCTGCCGCCGATCATCGCCTGGCCGAACTGACCATGAACAAGC
TATACGATAAAATTCCGGTCGCCGTTTGGAAATTTGTAAGATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT166342 WP_003406322.1 NZ_CP058236:c1394962-1394693 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT166342 NZ_CP074137:c1389810-1389442 [Serratia sp. JSRIV006]
ATGGATGAGTATTCGCCTAAAAGGCACGATATTGCTCAACTCAAATTTTTGTGTGAAAATTTGTACGACGAAGGCATCGC
TACCCTGGGTGACAGCCATCACGGCTGGGTAAACGATCCAACGTCCGCCGTCAATCTGCAGCTTAATGAGCTGATCGAAC
ATATTGCTTCGTTTGTAATGAGTTTTAAAATTAAATACATGGACGAAGGTGATTTATCGGAACTGGTCGAAGAGTACCTC
GACGATACCTACACGCTGTTTAGCAGCTACGGTATTAATGACTCCGATTTGCGTCGCTGGCAAAAAACCAAGGCACGCAC
ATTCAGATTGTTCTCAGGAGAGGGCGTCTGTACCACAATGAAAACTTAG

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2