Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1236638..1237269 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag HWS75_RS05910 Protein ID WP_003405820.1
Coordinates 1236638..1236949 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag HWS75_RS05915 Protein ID WP_003405836.1
Coordinates 1236949..1237269 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS05890 1232120..1233544 - 1425 WP_003405805.1 class II fumarate hydratase -
HWS75_RS05895 1233575..1234663 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
HWS75_RS05900 1234719..1235363 + 645 WP_003915494.1 DUF4245 domain-containing protein -
HWS75_RS05905 1235370..1236526 - 1157 Protein_1164 AI-2E family transporter -
HWS75_RS05910 1236638..1236949 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
HWS75_RS05915 1236949..1237269 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
HWS75_RS05920 1237279..1238815 + 1537 Protein_1167 carboxylesterase/lipase family protein -
HWS75_RS05925 1238822..1239934 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
HWS75_RS05930 1239944..1240201 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
HWS75_RS05935 1240191..1241438 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
HWS75_RS05940 1241435..1242073 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T166339 WP_003405820.1 NZ_CP058236:c1236949-1236638 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T166339 NZ_CP074137:c665942-665625 [Serratia sp. JSRIV006]
ATGAAACAATTTTCTGTTTATAAAAATCAATCTAAAAACAAAAAAGCCTATCCTTTCTTTATCGTTGTTCAGTCCGATTT
ACTCGATCACCTTAGCACTCGTTTGGTCATGCCCTTGGCTTTAAAGCAAGCAACAAACTCACAGGTCAAAGCACTGACTC
CTGTTTTGTCTGTGGATCAACAAGATTACGTGATCCTTACTAGTTTACTGACGACTACGGATGTCAAAAATCTTAATGCA
GATTGCCTAGTTACCAATGCAGCCCATCTGCGTGATGAGCTGGTTGCGGCCATCGACCTGTTAGTTTTGGGCATTTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT166339 WP_003405836.1 NZ_CP058236:c1237269-1236949 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT166339 NZ_CP074137:c666187-665942 [Serratia sp. JSRIV006]
ATGGGAACCGTTTCAGTAATAAAAAAGCGCAATACTAACGTGTACTTAAGTGTCGACCTGATCGAAAAGGCTAAAGCATT
AGACCTAAACTTATCGGCTACACTAAACCACGCATTAGAACTCGCAGTGAAGAAGGGGCAACGTGAACGTTGGTTAGCGG
AAAATCGTGCTGGTCTTGAAGCATTGAATGGCTTCGTTGAGGAGAACGGCCTTTTTTCTGATGATGCTGACTTTGGTGTC
CTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References