Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 845919..846628 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag HWS75_RS03995 Protein ID WP_003403837.1
Coordinates 846200..846628 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag HWS75_RS03990 Protein ID WP_003403834.1
Coordinates 845919..846176 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS03985 843141..845828 + 2688 Protein_789 PE family protein -
HWS75_RS03990 845919..846176 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
HWS75_RS03995 846200..846628 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
HWS75_RS04000 846709..846846 - 138 WP_003403839.1 hypothetical protein -
HWS75_RS04010 847005..847250 + 246 WP_003403841.1 hypothetical protein -
HWS75_RS04015 847319..848203 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
HWS75_RS04020 848214..849386 - 1173 WP_003403845.1 acyl-CoA dehydrogenase family protein -
HWS75_RS04025 849393..850925 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T166335 WP_003403837.1 NZ_CP058236:846200-846628 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T166335 NZ_CP074137:180288-180638 [Serratia sp. JSRIV006]
TTGTGGACTGTTATTTTTACCTCGACATTTGATTCTTGGTTGCAAGAGCAGGAAGAAGGGATGCAGGAGAAGGTACTGGC
TGACCTGATGAACCTGGAGACGTATGGGCCTCAACTGCCACGTCCTTACGCTGACACGGTAAAAGGTTCAAGATACAAGA
ATATGAAAGAGCTGCGTGTTCAGTATTCGGGCCGCCCAATCCGTGCCTTTTTTGTTTTCGACCCCAAACGCCAAGCCATT
GTGTTGTGCGCTGGTGATAAAAGTAATGATAAGCGTTTTTACGAGACAATGATCCGAATAGCGGATGATGAATTTACGGC
GTATTTAGCCACACAAGAGGTATCCAAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT166335 WP_003403834.1 NZ_CP058236:845919-846176 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT166335 NZ_CP074137:180635-180934 [Serratia sp. JSRIV006]
ATGAAAACGTTACGTGATGCAGTCGCTGCCCGTTCTCTTGAGAGCCAAGCCCGTATCAAGGAAATGGCCGACGAAATGAT
GCTAGAAACAGGTTTGCAACTGATGCGTGATGAGCTGCAACTGTCACAGAAAAGCCTGGCCGAAGCTATGGGCGTAAGCC
AATCCGCGGTTGCACAAATAGAGCAGCGTGGTAATGACGTAAAGTTAGCGACGCTAAAACGCTATATTGAAGCTATGGGT
GGGAAGTTGAGTCTGACTGTAGAGATGCCGGAAGGCGGTGGGCGAGTCTTCCATATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References