Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 759384..759924 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name mazF Uniprot ID P9WII0
Locus tag HWS75_RS03505 Protein ID WP_003403376.1
Coordinates 759384..759692 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag HWS75_RS03510 Protein ID WP_003403381.1
Coordinates 759679..759924 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS03480 754699..756204 + 1506 WP_235733078.1 carotenoid cleavage oxygenase -
HWS75_RS03485 756285..757295 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
HWS75_RS03490 757683..758066 - 384 WP_003403365.1 ribonuclease VapC6 -
HWS75_RS03495 758161..758316 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
HWS75_RS03500 758392..759108 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
HWS75_RS03505 759384..759692 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HWS75_RS03510 759679..759924 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
HWS75_RS03515 760034..760471 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
HWS75_RS03520 760468..760722 - 255 WP_003911263.1 antitoxin VapB7 -
HWS75_RS03525 760836..763199 + 2364 WP_003403397.1 arylsulfatase AtsD -
HWS75_RS03530 763262..763588 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HWS75_RS03535 763500..763838 + 339 WP_003403405.1 PIN domain-containing protein -
HWS75_RS03540 763835..764008 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-101)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11320.10 Da        Isoelectric Point: 11.6554

>T166332 WP_003403376.1 NZ_CP058236:c759692-759384 [Mycobacterium tuberculosis]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC

Download         Length: 309 bp

>T166332 NZ_CP074133:c966300-966040 [Nocardiopsis changdeensis]
GTGAGGCTCGTCTGGTCCCAGAGCGCCTGGGAGGACTACGTCTGGTGGCAGGGGCAGGACCGCAGGATCCTCAAGCGCAT
CAACGCTCTCGTCAAGGACATCGAGCGCAACGGCAACGAGGGCATGGGCAAGCCCGAACCCCTGAGGCACGGCTTCCAGG
GCTACTGGTCCCGCAGGATCACCGACGAGCACCGGCTGGTGTACAAGCTCGCCGGCGACGAGATCCGCATCGCCGCCTGC
CGCTACCACTACGGCAAGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT166332 WP_003403381.1 NZ_CP058236:c759924-759679 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT166332 NZ_CP074133:c966548-966297 [Nocardiopsis changdeensis]
TTGAAGACCATGAGCTACACCGAATCCCGCGCCAACTACGCAGCCACCCTCGACGCCGTCGTGAACGACAGAGAAGAAGT
GGTGATCACGAGAGCCGGACACGAACCCGTCGTCATGATGGCCCTGTCCGAGTACGAGACCCTGAAGGAGACCGCCTACC
TCCTGCGCAGCCCGGAGAACGCCCGCCGCCTGGTCTCCGCCATCGAGGAACTGGAGTCCGATCAGGGCATAGAGCGCGAG
TTGGCCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSE5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References