Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 757683..758316 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag HWS75_RS03490 Protein ID WP_003403365.1
Coordinates 757683..758066 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag HWS75_RS03495 Protein ID WP_003403368.1
Coordinates 758161..758316 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS03465 752975..753511 + 537 WP_003403341.1 50S ribosomal protein L10 -
HWS75_RS03470 753548..753940 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
HWS75_RS03475 753933..754628 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
HWS75_RS03480 754699..756204 + 1506 WP_235733078.1 carotenoid cleavage oxygenase -
HWS75_RS03485 756285..757295 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
HWS75_RS03490 757683..758066 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
HWS75_RS03495 758161..758316 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HWS75_RS03500 758392..759108 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
HWS75_RS03505 759384..759692 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
HWS75_RS03510 759679..759924 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
HWS75_RS03515 760034..760471 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
HWS75_RS03520 760468..760722 - 255 WP_003911263.1 antitoxin VapB7 -
HWS75_RS03525 760836..763199 + 2364 WP_003403397.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T166331 WP_003403365.1 NZ_CP058236:c758066-757683 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T166331 NZ_CP074132:6273531-6273950 [Nocardiopsis akebiae]
GTGACCAAGACCTATCTCCTCGACACCTCCGCCTGGTTGGAGTACCTGGGCGGAACCGGTTCCGAAACCCACCTGTTCGT
CCGTCAGCTTCGTGACGATCGGGAGAACGTGGCGACCACCGATCCGGTGATCTGCGAACTCCTGTCCGGAGCCAAGACCG
AGAAGGCGTTCTTCCAGCTGGACGCGATGCTTCAGGCGCAGACCCGGCTGACGGTCGAACCGACCTTCGACTTCCGGGAG
TCCGCGATGCTCTATCGCGGAGCACGGTCCAAGGGCAAGACGATCCGCAAACACATGGACTGCCTCATCGCGGCCGTCGC
CCTGCGCACCGACGCGGTCCTCGTGCACTGCGACCGCGACTTCGACGACCTCGCCGAGGTGTTCCCCCGGCTGCGCGTAC
AGCGGCACGACCAGAACTGA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT166331 WP_003403368.1 NZ_CP058236:c758316-758161 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT166331 NZ_CP074132:6273311-6273526 [Nocardiopsis akebiae]
ATGAGTCGCACAAACATTGACATCGACGACGAACTGGTCACAACGGTCATGGAGAAGTACGGCCTGAGGACCAAGCGCGA
GGCGGTGGACTTCGGTCTCCGCCACGTGGCGGGAAGCGGTGACCGTTACGAGATGATGCTGGAGCTCGAGGGAAGCGACG
TCTGGGAAGGCGATCTGGACGAGATGCGCCGTTCGGGCTTCGAGGACGAGAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References