Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 714947..715572 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag HWS75_RS03270 Protein ID WP_003403218.1
Coordinates 715171..715572 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag HWS75_RS03265 Protein ID WP_003403213.1
Coordinates 714947..715174 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS03240 710126..710347 - 222 WP_003898525.1 DUF4926 domain-containing protein -
HWS75_RS03245 710489..711094 + 606 WP_003898526.1 hypothetical protein -
HWS75_RS03250 711113..713680 - 2568 WP_235733075.1 SEC-C metal-binding domain-containing protein -
HWS75_RS03255 713764..714513 + 750 WP_003898528.1 hypothetical protein -
HWS75_RS03260 714510..714752 + 243 WP_003403210.1 hypothetical protein -
HWS75_RS03265 714947..715174 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
HWS75_RS03270 715171..715572 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
HWS75_RS03275 715701..715784 + 84 Protein_650 galactose-1-phosphate uridylyltransferase -
HWS75_RS03280 715803..716885 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
HWS75_RS03285 716882..717973 + 1092 WP_003900977.1 galactokinase -
HWS75_RS03290 718368..719525 + 1158 WP_003903091.1 hypothetical protein -
HWS75_RS03295 719536..720483 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T166328 WP_003403218.1 NZ_CP058236:715171-715572 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T166328 NZ_CP074123:64942-65094 [Escherichia coli]
ATGCCACAGCGAACATTTTTAATGATGTTGATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGGCTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT166328 WP_003403213.1 NZ_CP058236:714947-715174 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT166328 NZ_CP074123:c64892-64830 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References