Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 707409..708052 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag HWS75_RS03220 Protein ID WP_003403187.1
Coordinates 707651..708052 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag HWS75_RS03215 Protein ID WP_003403184.1
Coordinates 707409..707654 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS03180 702684..703214 - 531 WP_003917320.1 two component system sensor kinase HK2 -
HWS75_RS03185 703198..703893 - 696 WP_003918099.1 two-component system response regulator TcrA -
HWS75_RS03190 704016..704327 + 312 WP_003403164.1 hypothetical protein -
HWS75_RS03195 704399..705353 + 955 Protein_634 DUF1259 domain-containing protein -
HWS75_RS03200 705594..706178 + 585 WP_031667543.1 IS607-like element IS1536 family transposase -
HWS75_RS03205 706180..706891 + 712 Protein_636 IS607 family element RNA-guided endonuclease TnpB -
HWS75_RS03210 706894..707364 + 471 WP_003898523.1 hypothetical protein -
HWS75_RS03215 707409..707654 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HWS75_RS03220 707651..708052 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
HWS75_RS03225 708043..708222 + 180 Protein_640 hypothetical protein -
HWS75_RS03230 708640..708837 - 198 WP_003403191.1 hypothetical protein -
HWS75_RS03235 708917..710074 - 1158 WP_003403193.1 hypothetical protein -
HWS75_RS03240 710126..710347 - 222 WP_003898525.1 DUF4926 domain-containing protein -
HWS75_RS03245 710489..711094 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T166327 WP_003403187.1 NZ_CP058236:707651-708052 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T166327 NZ_CP074123:2255-2533 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAGCGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAATGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT166327 WP_003403184.1 NZ_CP058236:707409-707654 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT166327 NZ_CP074123:1986-2255 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACAACAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCACGGCGATGTGCTTCCCCATGACATGGTCGAATCCTCCGCTACTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References