Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 681869..682488 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HWS75_RS03085 Protein ID WP_235733073.1
Coordinates 682081..682488 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag HWS75_RS03080 Protein ID WP_003403039.1
Coordinates 681869..682084 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS03070 680397..681155 + 759 WP_003898511.1 Mut7-C RNAse domain-containing protein -
HWS75_RS03075 681284..681775 - 492 WP_003403017.1 mycobacterial cell wall protein Rv0580c -
HWS75_RS03080 681869..682084 + 216 WP_003403039.1 type II toxin-antitoxin system antitoxin VapB26 Antitoxin
HWS75_RS03085 682081..682488 + 408 WP_235733073.1 type II toxin-antitoxin system toxin ribonuclease C26 Toxin
HWS75_RS03090 682548..683234 - 687 WP_003909258.1 LpqN/LpqT family lipoprotein -
HWS75_RS03095 683388..686021 + 2634 WP_003403055.1 GH92 family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14499.49 Da        Isoelectric Point: 4.4493

>T166324 WP_235733073.1 NZ_CP058236:682081-682488 [Mycobacterium tuberculosis]
VIIDTSALLAYFDVAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

>T166324 NZ_CP074121:c79321-79172 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT166324 WP_003403039.1 NZ_CP058236:681869-682084 [Mycobacterium tuberculosis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp

>AT166324 NZ_CP074121:79365-79426 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5X3T
AlphaFold DB A0A7U4BSA2

References