Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0299-vapB/-
Location 367775..368346 Replicon chromosome
Accession NZ_CP058236
Organism Mycobacterium tuberculosis strain 060827

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag HWS75_RS01600 Protein ID WP_003401560.1
Coordinates 367775..368077 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag HWS75_RS01605 Protein ID WP_003401563.1
Coordinates 368125..368346 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWS75_RS01580 363202..364005 - 804 WP_003401540.1 Stf0 family sulphotransferase -
HWS75_RS01585 364015..365412 - 1398 WP_003401544.1 sulfatase -
HWS75_RS01590 365591..367408 + 1818 WP_235733064.1 PE family protein -
HWS75_RS01595 367551..367778 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
HWS75_RS01600 367775..368077 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
HWS75_RS01605 368125..368346 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
HWS75_RS01610 368343..368768 + 426 WP_003401566.1 PIN domain nuclease -
HWS75_RS01615 368903..369535 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
HWS75_RS01620 369532..370440 + 909 WP_003900117.1 protochlorophyllide reductase -
HWS75_RS01625 370448..371038 - 591 WP_229298012.1 hypothetical protein -
HWS75_RS01630 371031..371081 - 51 Protein_322 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T166320 WP_003401560.1 NZ_CP058236:367775-368077 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T166320 NZ_CP074120:3773762-3774058 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT166320 WP_003401563.1 NZ_CP058236:368125-368346 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT166320 NZ_CP074120:3774060-3774455 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References