Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VbhT-dinJ/RelB(antitoxin)
Location 571117..572108 Replicon chromosome
Accession NZ_CP058235
Organism Bartonella alsatica strain CIP 105477

Toxin (Protein)


Gene name VbhT Uniprot ID -
Locus tag HWV54_RS02365 Protein ID WP_156785837.1
Coordinates 571458..572108 (-) Length 217 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID J1IWH4
Locus tag HWV54_RS02360 Protein ID WP_005864571.1
Coordinates 571117..571389 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWV54_RS02335 566973..567266 + 294 WP_005864579.1 hypothetical protein -
HWV54_RS02340 567263..567934 + 672 WP_005864578.1 virB8 family protein -
HWV54_RS02345 567938..568792 + 855 WP_005864576.1 P-type conjugative transfer protein VirB9 -
HWV54_RS02350 568817..569953 + 1137 WP_005864575.1 type IV secretion system protein VirB10 -
HWV54_RS02355 569966..571030 + 1065 WP_005864573.1 P-type DNA transfer ATPase VirB11 -
HWV54_RS02360 571117..571389 - 273 WP_005864571.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HWV54_RS02365 571458..572108 - 651 WP_156785837.1 BID domain-containing protein Toxin
HWV54_RS02370 572297..572395 + 99 Protein_448 type II toxin-antitoxin system RelE/ParE family toxin -
HWV54_RS02375 572413..572700 + 288 WP_005864567.1 HigA family addiction module antidote protein -
HWV54_RS02380 572750..573145 - 396 WP_005864563.1 hypothetical protein -
HWV54_RS02385 573979..574296 - 318 WP_005864561.1 hypothetical protein -
HWV54_RS02390 574293..574985 - 693 WP_005864560.1 ParA family protein -
HWV54_RS02395 575233..575484 + 252 WP_005864558.1 hypothetical protein -
HWV54_RS02400 575481..575879 + 399 WP_004857195.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bartonella effector protein, BID domain

(3-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-88)


Sequences

Toxin        


Download         Length: 217 a.a.        Molecular weight: 25087.50 Da        Isoelectric Point: 10.2384

>T166317 WP_156785837.1 NZ_CP058235:c572108-571458 [Bartonella alsatica]
MFKELNSRLAFIYKDPQEVALRIEQTILAGKGDKLSDILEREPDRAGELRGSDRFIDKLKSTGKERKEALSHVSRTISSI
EKLQSLYKNSYETHINRLTREWERLKVEVPSLSQEAVTFMKNVEAGRDSYSKIPEQVNKEFSKLQSALDKRFGQDAIHKQ
DFDLSKAIPQNQRHDKKLVNELQTAVKFLQQRHVEEQNNAITQTKSKDVMKSRKKT

Download         Length: 651 bp

>T166317 NZ_CP074120:3237467-3237574 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10316.83 Da        Isoelectric Point: 4.5746

>AT166317 WP_005864571.1 NZ_CP058235:c571389-571117 [Bartonella alsatica]
MSVSVDSKDVVRARIDKHLKKEAHEILATLGLTVSDFIRIALTKVVNERGLPFDMYVPNAETLEIFEKTDRGEDVFYAED
MDDLFKKLDI

Download         Length: 273 bp

>AT166317 NZ_CP074120:c3237419-3237353 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB J1IWH4

References