Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876443..877097 Replicon chromosome
Accession NZ_CP058226
Organism Klebsiella pneumoniae strain KPCZA02

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag HWQ20_RS04425 Protein ID WP_004144731.1
Coordinates 876690..877097 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HWQ20_RS04420 Protein ID WP_002916312.1
Coordinates 876443..876709 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ20_RS04395 (HWQ20_04395) 871599..873032 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HWQ20_RS04400 (HWQ20_04400) 873151..873879 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HWQ20_RS04405 (HWQ20_04405) 873929..874240 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HWQ20_RS04410 (HWQ20_04410) 874404..875063 + 660 WP_002916317.1 hemolysin III family protein -
HWQ20_RS04415 (HWQ20_04415) 875214..876197 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HWQ20_RS04420 (HWQ20_04420) 876443..876709 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HWQ20_RS04425 (HWQ20_04425) 876690..877097 + 408 WP_004144731.1 protein YgfX Toxin
HWQ20_RS04430 (HWQ20_04430) 877104..877625 - 522 WP_002916308.1 flavodoxin FldB -
HWQ20_RS04435 (HWQ20_04435) 877726..878622 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HWQ20_RS04440 (HWQ20_04440) 878645..879358 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HWQ20_RS04445 (HWQ20_04445) 879364..881097 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T166288 WP_004144731.1 NZ_CP058226:876690-877097 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T166288 NZ_CP074112:2694789-2695361 [Idiomarina loihiensis]
ATGAGCTCAAGCTATACGGTTATCTTTGATGCTTGCGTATTGTATCCGGCACCGCTGAGAAGTCTGCTGATGTATTTGGC
GCTCAGCGGTGAGTTCAGGGCTCGTTGGACGAATGATATTCATGACGAATGGATTAGAAATGTATTAGCGAATCGACCAG
ACTTAACGCGCGAGCAATTGGAGAATGTGCGAAATTTAATGGACAAGCACGTACCTGGGGCAATTGTGCAAAATTATCAT
CCGCTTATCTCGTCAATATCTTTACCCGATGAAGATGATCGTCATGTGGTTGCTGCAGCAATACAAACCCGAGCGGAGGC
AATTGTGACGTTTAATTTAAAAGACTTCCCCGATAATCAACTTAGTCAATATAATCTTAAGGCTATTCATCCGGATGATT
TTATAACAGATTTGATGGAGCTAAACATCGTAGCTGTTATTCAAGCTGTTAGACATCATCGTGCAAGTTTGAAAAATCCG
CCGTTTACCGCCACTCAGTATCTTGATTGTTTGTTGAAGCAGAAATTACCAGAAGCCGTTTCACGGCTAAGTGAATTTAA
AGCGCTATTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT166288 WP_002916312.1 NZ_CP058226:876443-876709 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT166288 NZ_CP074112:2694337-2694789 [Idiomarina loihiensis]
ATGAATACTTATGAACAACTACCGACTGCGCAGGAATCTGCACTAGCGAAATTGTGTAGCCAAGAACTTGCTGCGGTGAT
CGAAACGAAGTTAGATGTTCAGTCTTTGTCATTAAGCTCTCCAGATGGCCAGCTAAAGCAAGTTGAGATCCCGGTGAGTG
CGCTTCGCTTAATGGTGAATTTACTGACTGAGCTAGGCGAAGGCAATACCGTGAAATTAGTGCCCATACATGCTGAACTG
ACAACACAAGAGGCTGCAGATTTACTGAATGTGTCTCGTCCAACAGTAATTAAGTTATTGGATGATGGAACTGTACCATT
TCATCGAGTTGGTAACCGAAGAAAAGTGCGCTTTAACGACATAAGACAGTATCAAAACCAACTAGAACAGAAGCGACTGA
AAGCTCTCAATGAATTGTCGAAGATGGATCAAGAGTTAGGGTTAGGCTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References