166284

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 47333..47868 Replicon plasmid p550_IncB_O_K_Z
Accession NZ_CP058225
Organism Escherichia coli strain 550

Toxin (Protein)


Gene name relE Uniprot ID T2HS21
Locus tag HWQ66_RS24755 Protein ID WP_000222775.1
Coordinates 47581..47868 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T2HSA2
Locus tag HWQ66_RS24750 Protein ID WP_001139207.1
Coordinates 47333..47584 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ66_RS24725 42475..43095 - 621 WP_000176497.1 DUF1449 family protein -
HWQ66_RS24730 43362..44027 - 666 WP_000154143.1 hypothetical protein -
HWQ66_RS24735 44168..44809 - 642 WP_000335846.1 transcription termination factor NusG -
HWQ66_RS24740 45512..46384 + 873 WP_000729440.1 incFII family plasmid replication initiator RepA -
HWQ66_RS24745 47079..47246 + 168 WP_000841010.1 hypothetical protein -
HWQ66_RS24750 47333..47584 + 252 WP_001139207.1 plasmid stabilization protein Antitoxin
HWQ66_RS24755 47581..47868 + 288 WP_000222775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HWQ66_RS24760 47878..48423 + 546 WP_000926984.1 hypothetical protein -
HWQ66_RS24765 49075..49677 - 603 WP_000517694.1 hypothetical protein -
HWQ66_RS24770 50031..50270 + 240 Protein_55 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..100306 100306


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11142.17 Da        Isoelectric Point: 10.6261

>T166284 WP_000222775.1 NZ_CP058225:47581-47868 [Escherichia coli]
MTYTVKFRDDALREWLKLDKSVQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

>T166284 NZ_CP074112:c1737135-1736833 [Idiomarina loihiensis]
ATGGCTGAAGTAATCTGGACAGAGCCAGCCCTCCAAGAACTTGATGCTATTGCTGAGTATATTGCTTTGGACAATCCTGC
TGCCGCAAGCGATCTCGTTAAGGAAGTTTTCGGTAAGACAGAGCGTTTGGAAAATTTCCCCAAATCGGGGCGGATTCCTC
CAGAGCTCCCGGATTCGGTATACAGGGAGGTAGTGGTTCCACCGTGTCGCATTTTTTATCGTGAGGATGAGCAGCGGGTT
CTCGTCCTCTATGTCATGCGAGAGGAGCGGCAACTTCGTGCGTTCATGCTTGGAAACAGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9216.45 Da        Isoelectric Point: 4.0927

>AT166284 WP_001139207.1 NZ_CP058225:47333-47584 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDAMDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT166284 NZ_CP074112:c1737380-1737123 [Idiomarina loihiensis]
ATGAAAGTTGAGCTAGTTACGAACCTCAAGCGCCAAGCTACAAAGATTCTGGCAGATCTGCACTTGTCGAAAGAGCCCGT
ATTGATTACGGAGCATGGCCAGCCATCTGCATACCTTGTTGATGTGCAAGATTATGAATTCATGCAGCGTCGGCTTGAGC
TGCTTGAGGGGCTCTCTCGGGGAGAGCGTGCTGTACTTGAGGGAAGAACGTATAGCCAAAGTGAGGCCAGAGAGAAAATG
AGTAAATGGCTGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T2HS21

Antitoxin

Source ID Structure
AlphaFold DB A0A754EQ65

References