Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3585512..3587100 Replicon chromosome
Accession NZ_CP058223
Organism Escherichia coli strain 550

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HWQ66_RS16905 Protein ID WP_001546825.1
Coordinates 3585778..3587100 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HWQ66_RS16900 Protein ID WP_001296726.1
Coordinates 3585512..3585778 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ66_RS16895 3583901..3585301 + 1401 WP_001376867.1 autotransporter outer membrane beta-barrel domain-containing protein -
HWQ66_RS16900 3585512..3585778 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HWQ66_RS16905 3585778..3587100 + 1323 WP_001546825.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
HWQ66_RS16910 3587498..3588397 - 900 WP_001057776.1 LysR family transcriptional regulator -
HWQ66_RS16915 3588537..3588845 + 309 WP_001221046.1 hypothetical protein -
HWQ66_RS16920 3588854..3589543 + 690 WP_000801313.1 type 1 glutamine amidotransferase domain-containing protein -
HWQ66_RS16925 3589617..3590564 + 948 WP_000854796.1 aldo/keto reductase -
HWQ66_RS16930 3590667..3590822 + 156 WP_001322415.1 hypothetical protein -
HWQ66_RS16935 3590782..3591201 + 420 WP_001322416.1 amidohydrolase family protein -
HWQ66_RS16940 3591152..3591343 + 192 WP_001469139.1 amidohydrolase family protein -
HWQ66_RS16945 3591494..3592066 + 573 WP_000789913.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49331.00 Da        Isoelectric Point: 8.1369

>T166276 WP_001546825.1 NZ_CP058223:3585778-3587100 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHCRLSREYGIK

Download         Length: 1323 bp

>T166276 NZ_CP074105:173937-174203 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT166276 WP_001296726.1 NZ_CP058223:3585512-3585778 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp

>AT166276 NZ_CP074105:173674-173937 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACAGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References