Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2106261..2106921 Replicon chromosome
Accession NZ_CP058223
Organism Escherichia coli strain 550

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HWQ66_RS09950 Protein ID WP_029701967.1
Coordinates 2106508..2106921 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HWQ66_RS09945 Protein ID WP_000354046.1
Coordinates 2106261..2106527 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HWQ66_RS09920 2101549..2102292 + 744 WP_000951964.1 SDR family oxidoreductase -
HWQ66_RS09925 2102349..2103782 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
HWQ66_RS09930 2103827..2104138 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
HWQ66_RS09935 2104302..2104961 + 660 WP_000250274.1 hemolysin III family protein -
HWQ66_RS09940 2105038..2106018 - 981 WP_000886083.1 tRNA-modifying protein YgfZ -
HWQ66_RS09945 2106261..2106527 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HWQ66_RS09950 2106508..2106921 + 414 WP_029701967.1 protein YgfX Toxin
HWQ66_RS09955 2106955..2107476 - 522 WP_001055874.1 flavodoxin FldB -
HWQ66_RS09960 2107588..2108484 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HWQ66_RS09965 2108508..2109218 + 711 WP_029701969.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HWQ66_RS09970 2109224..2110957 + 1734 WP_029701971.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16305.25 Da        Isoelectric Point: 11.7064

>T166266 WP_029701967.1 NZ_CP058223:2106508-2106921 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLLHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQRSR

Download         Length: 414 bp

>T166266 NZ_CP074098:c3728733-3728365 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT166266 WP_000354046.1 NZ_CP058223:2106261-2106527 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT166266 NZ_CP074098:c3728951-3728730 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References