Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4698041..4698876 Replicon chromosome
Accession NZ_CP058222
Organism Escherichia coli strain CFT073

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VR61
Locus tag HW370_RS22850 Protein ID WP_000854747.1
Coordinates 4698499..4698876 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HW370_RS22845 Protein ID WP_024182258.1
Coordinates 4698041..4698409 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW370_RS22810 (4693953) 4693953..4694633 + 681 WP_001282928.1 WYL domain-containing protein -
HW370_RS22815 (4694781) 4694781..4695458 + 678 WP_001097307.1 hypothetical protein -
HW370_RS22820 (4695464) 4695464..4695697 + 234 WP_001278280.1 DUF905 family protein -
HW370_RS22825 (4695787) 4695787..4696605 + 819 WP_001175140.1 DUF932 domain-containing protein -
HW370_RS22830 (4696696) 4696696..4697181 + 486 WP_000860054.1 antirestriction protein -
HW370_RS22835 (4697196) 4697196..4697672 + 477 WP_001186756.1 RadC family protein -
HW370_RS22840 (4697741) 4697741..4697962 + 222 WP_000692312.1 DUF987 domain-containing protein -
HW370_RS22845 (4698041) 4698041..4698409 + 369 WP_024182258.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HW370_RS22850 (4698499) 4698499..4698876 + 378 WP_000854747.1 TA system toxin CbtA family protein Toxin
HW370_RS22855 (4698873) 4698873..4699361 + 489 WP_000761667.1 DUF5983 family protein -
HW370_RS22860 (4699373) 4699373..4699570 + 198 WP_000839291.1 DUF957 domain-containing protein -
HW370_RS22865 (4699655) 4699655..4700173 + 519 Protein_4484 DUF4942 domain-containing protein -
HW370_RS22870 (4700239) 4700239..4700994 - 756 WP_000065240.1 IS21-like element ISEc10 family helper ATPase IstB -
HW370_RS22875 (4700991) 4700991..4702490 - 1500 WP_000174402.1 IS21-like element ISEc10 family transposase -
HW370_RS22880 (4702584) 4702584..4702925 + 342 Protein_4487 DUF4942 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - htpB / papI / papB / papA / papH / papC / papD / papJ / papK / papE / papF / papG 4634831..4702490 67659


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14095.03 Da        Isoelectric Point: 6.8524

>T166254 WP_000854747.1 NZ_CP058222:4698499-4698876 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Download         Length: 378 bp

>T166254 NZ_CP074096:4563433-4563924 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGAACCATCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13497.32 Da        Isoelectric Point: 6.7344

>AT166254 WP_024182258.1 NZ_CP058222:4698041-4698409 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLGQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKK

Download         Length: 369 bp

>AT166254 NZ_CP074096:4563143-4563436 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCACAGGCTTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H2VFZ1


Antitoxin

Source ID Structure

References