Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 878021..878855 Replicon chromosome
Accession NZ_CP058222
Organism Escherichia coli strain CFT073

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2VDB0
Locus tag HW370_RS04290 Protein ID WP_000854688.1
Coordinates 878021..878398 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H2VAY1
Locus tag HW370_RS04295 Protein ID WP_001285596.1
Coordinates 878475..878855 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW370_RS04260 (874414) 874414..874584 - 171 Protein_841 IS110 family transposase -
HW370_RS04265 (875001) 875001..875935 - 935 Protein_842 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
HW370_RS04270 (875928) 875928..876323 - 396 WP_000208383.1 DUF6088 family protein -
HW370_RS04275 (876392) 876392..877237 - 846 WP_001280441.1 DUF4942 domain-containing protein -
HW370_RS04280 (877322) 877322..877519 - 198 WP_000839260.1 DUF957 domain-containing protein -
HW370_RS04285 (877536) 877536..878024 - 489 WP_000761701.1 DUF5983 family protein -
HW370_RS04290 (878021) 878021..878398 - 378 WP_000854688.1 TA system toxin CbtA family protein Toxin
HW370_RS04295 (878475) 878475..878855 - 381 WP_001285596.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HW370_RS04300 (878905) 878905..879549 - 645 WP_000094917.1 hypothetical protein -
HW370_RS04305 (879568) 879568..879789 - 222 WP_000692329.1 DUF987 domain-containing protein -
HW370_RS04310 (879852) 879852..880328 - 477 WP_001186726.1 RadC family protein -
HW370_RS04315 (880344) 880344..880829 - 486 WP_000849564.1 antirestriction protein -
HW370_RS04320 (880884) 880884..881702 - 819 WP_001234616.1 DUF932 domain-containing protein -
HW370_RS04325 (881803) 881803..882036 - 234 WP_001119727.1 DUF905 family protein -
HW370_RS04330 (882115) 882115..882570 - 456 WP_000581502.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14014.01 Da        Isoelectric Point: 8.5221

>T166230 WP_000854688.1 NZ_CP058222:c878398-878021 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T166230 NZ_CP074094:c1968307-1968204 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13897.70 Da        Isoelectric Point: 4.7959

>AT166230 WP_001285596.1 NZ_CP058222:c878855-878475 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCAVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT166230 NZ_CP074094:1968202-1968345 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VDB0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2VAY1

References