Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 45029..45861 | Replicon | chromosome |
| Accession | NZ_CP058222 | ||
| Organism | Escherichia coli strain CFT073 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0H2VCF5 |
| Locus tag | HW370_RS00230 | Protein ID | WP_000854681.1 |
| Coordinates | 45029..45406 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A3Z9KHH3 |
| Locus tag | HW370_RS00235 | Protein ID | WP_021562928.1 |
| Coordinates | 45496..45861 (-) | Length | 122 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HW370_RS00195 (40163) | 40163..40456 | - | 294 | WP_001297978.1 | protein YicS | - |
| HW370_RS00200 (40678) | 40678..41496 | + | 819 | WP_000779409.1 | lipoprotein NlpA | - |
| HW370_RS00205 (41500) | 41500..42423 | - | 924 | WP_001351210.1 | carboxylate/amino acid/amine transporter | - |
| HW370_RS00210 (42590) | 42590..43087 | - | 498 | WP_000509808.1 | hypothetical protein | - |
| HW370_RS00215 (43683) | 43683..44525 | - | 843 | WP_001280503.1 | DUF4942 domain-containing protein | - |
| HW370_RS00220 (44610) | 44610..44807 | - | 198 | WP_023563519.1 | DUF957 domain-containing protein | - |
| HW370_RS00225 (44883) | 44883..45032 | - | 150 | Protein_44 | DUF5983 family protein | - |
| HW370_RS00230 (45029) | 45029..45406 | - | 378 | WP_000854681.1 | TA system toxin CbtA family protein | Toxin |
| HW370_RS00235 (45496) | 45496..45861 | - | 366 | WP_021562928.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HW370_RS00240 (45940) | 45940..46161 | - | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| HW370_RS00245 (46224) | 46224..46700 | - | 477 | WP_001186171.1 | RadC family protein | - |
| HW370_RS00250 (46715) | 46715..47200 | - | 486 | WP_000206666.1 | antirestriction protein | - |
| HW370_RS00255 (47292) | 47292..48110 | - | 819 | WP_001175163.1 | DUF932 domain-containing protein | - |
| HW370_RS00260 (48200) | 48200..48433 | - | 234 | WP_001278287.1 | DUF905 family protein | - |
| HW370_RS00265 (48439) | 48439..49116 | - | 678 | WP_001097301.1 | hypothetical protein | - |
| HW370_RS00270 (49264) | 49264..49944 | - | 681 | WP_001278650.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13963.89 Da Isoelectric Point: 7.4348
>T166228 WP_000854681.1 NZ_CP058222:c45406-45029 [Escherichia coli]
MKTLPDTHIREASHCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTSHNYRTVNNITLGKHPEAKR
MKTLPDTHIREASHCPSPVTIWQTLLTRLLDQHYGLALNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTSHNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T166228 NZ_CP074094:c528440-528222 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 122 a.a. Molecular weight: 13528.32 Da Isoelectric Point: 6.4648
>AT166228 WP_021562928.1 NZ_CP058222:c45861-45496 [Escherichia coli]
VSDTLPGTTHPDNNNRPWWGLPCTVMPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSGE
LSPRYQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKT
VSDTLPGTTHPDNNNRPWWGLPCTVMPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSGE
LSPRYQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTPETKT
Download Length: 366 bp
>AT166228 NZ_CP074094:c528842-528468 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H2VCF5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3Z9KHH3 |