Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2991461..2992262 Replicon chromosome
Accession NZ_CP058220
Organism Escherichia coli strain 83972

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag HW371_RS14485 Protein ID WP_000854739.1
Coordinates 2991461..2991841 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag HW371_RS14490 Protein ID WP_001285482.1
Coordinates 2991888..2992262 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW371_RS14450 (2987052) 2987052..2987606 - 555 WP_001001909.1 molecular chaperone YcdY -
HW371_RS14455 (2987630) 2987630..2988367 - 738 WP_000283664.1 zinc-binding phosphatase -
HW371_RS14460 (2988422) 2988422..2989360 - 939 WP_000351287.1 glyoxylate/hydroxypyruvate reductase GhrA -
HW371_RS14470 (2989831) 2989831..2990674 - 844 Protein_2840 DUF4942 domain-containing protein -
HW371_RS14475 (2990759) 2990759..2990956 - 198 WP_000772027.1 DUF957 domain-containing protein -
HW371_RS14480 (2990976) 2990976..2991464 - 489 WP_001054232.1 DUF5983 family protein -
HW371_RS14485 (2991461) 2991461..2991841 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
HW371_RS14490 (2991888) 2991888..2992262 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HW371_RS14495 (2992312) 2992312..2992956 - 645 WP_000086763.1 hypothetical protein -
HW371_RS14500 (2992975) 2992975..2993196 - 222 WP_000692315.1 DUF987 domain-containing protein -
HW371_RS14505 (2993259) 2993259..2993735 - 477 WP_001186170.1 RadC family protein -
HW371_RS14510 (2993751) 2993751..2994224 - 474 WP_000855076.1 antirestriction protein -
HW371_RS14515 (2994487) 2994487..2995308 - 822 WP_001234710.1 DUF932 domain-containing protein -
HW371_RS14520 (2995487) 2995487..2995576 - 90 WP_230607454.1 DUF905 family protein -
HW371_RS14525 (2995719) 2995719..2996174 - 456 WP_000581502.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T166217 WP_000854739.1 NZ_CP058220:c2991841-2991461 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T166217 NZ_CP074092:c3679979-3679704 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT166217 WP_001285482.1 NZ_CP058220:c2992262-2991888 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT166217 NZ_CP074092:c3680242-3679982 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References