Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1914339..1915170 Replicon chromosome
Accession NZ_CP058220
Organism Escherichia coli strain 83972

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag HW371_RS09050 Protein ID WP_000854814.1
Coordinates 1914339..1914713 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag HW371_RS09055 Protein ID WP_001285586.1
Coordinates 1914802..1915170 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW371_RS09010 (1909735) 1909735..1910901 + 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
HW371_RS09015 (1911020) 1911020..1911493 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
HW371_RS09020 (1911691) 1911691..1912749 + 1059 WP_001200890.1 FUSC family protein -
HW371_RS09025 (1912921) 1912921..1913250 + 330 WP_000450409.1 DUF496 family protein -
HW371_RS09030 (1913351) 1913351..1913674 - 324 WP_223216378.1 EutP/PduV family microcompartment system protein -
HW371_RS09035 (1913653) 1913653..1913733 + 81 WP_023441679.1 hypothetical protein -
HW371_RS09040 (1914022) 1914022..1914102 - 81 Protein_1772 hypothetical protein -
HW371_RS09045 (1914148) 1914148..1914342 - 195 WP_000988601.1 DUF5983 family protein -
HW371_RS09050 (1914339) 1914339..1914713 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
HW371_RS09055 (1914802) 1914802..1915170 - 369 WP_001285586.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
HW371_RS09060 (1915244) 1915244..1915465 - 222 WP_000692323.1 DUF987 domain-containing protein -
HW371_RS09065 (1915534) 1915534..1916010 - 477 WP_001351157.1 RadC family protein -
HW371_RS09070 (1916026) 1916026..1916499 - 474 WP_000855074.1 antirestriction protein -
HW371_RS09075 (1916762) 1916762..1917583 - 822 WP_001234571.1 DUF932 domain-containing protein -
HW371_RS09080 (1917804) 1917804..1918214 - 411 WP_000846704.1 hypothetical protein -
HW371_RS09085 (1918230) 1918230..1918907 - 678 WP_001362823.1 hypothetical protein -
HW371_RS09090 (1919043) 1919043..1920113 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T166206 WP_000854814.1 NZ_CP058220:c1914713-1914339 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T166206 NZ_CP074088:37676-38146 [Klebsiella pneumoniae subsp. pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT166206 WP_001285586.1 NZ_CP058220:c1915170-1914802 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT166206 NZ_CP074088:37236-37679 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References