Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 1824924..1826397 Replicon chromosome
Accession NZ_CP058214
Organism Kaustia mangrovi strain R1DC25

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag HW532_RS08510 Protein ID WP_213163966.1
Coordinates 1824924..1825787 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag HW532_RS08515 Protein ID WP_213163967.1
Coordinates 1825780..1826397 (-) Length 206 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW532_RS22090 1820372..1821052 - 681 WP_246479742.1 DUF262 domain-containing protein -
HW532_RS08495 (HW532_08475) 1821049..1822206 - 1158 WP_213163964.1 restriction endonuclease subunit S -
HW532_RS08500 (HW532_08480) 1822200..1824608 - 2409 WP_213163965.1 type I restriction-modification system subunit M -
HW532_RS08505 (HW532_08485) 1824589..1824795 - 207 WP_054522784.1 hypothetical protein -
HW532_RS08510 (HW532_08490) 1824924..1825787 - 864 WP_213163966.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
HW532_RS08515 (HW532_08495) 1825780..1826397 - 618 WP_213163967.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
HW532_RS08520 (HW532_08500) 1826653..1827489 - 837 WP_213163968.1 LysR family transcriptional regulator -
HW532_RS08525 (HW532_08505) 1827588..1828568 + 981 WP_213163969.1 aldo/keto reductase -
HW532_RS08530 (HW532_08510) 1828577..1829746 + 1170 WP_213163970.1 alpha/beta fold hydrolase -
HW532_RS08535 (HW532_08515) 1829853..1831049 + 1197 WP_213163971.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1668529..1829896 161367


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-262)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(17-56)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 31991.69 Da        Isoelectric Point: 4.8516

>T166170 WP_213163966.1 NZ_CP058214:c1825787-1824924 [Kaustia mangrovi]
MAKEMKNIGASVRARLLNLSKAKGQSFDLVLTRFALERLLFRLSQSPQADRFVLKGAMLMMSWFDDPHRGTRDLDLLGFG
DPSEAAMLATFRDILAQDAEDGVVFDPDTLRIDRIREELDYGGLRLRAIASVGGAQINLTIDIGFGDALEPGAEVVDYPA
MLDFPPPRLRAYARETVIAEKFQAMVALGRANSRMKDFYDIWVLSRSFSFDDDRLAQAIAATFARRKTPIPTELPDALTP
AFAADEQKQRQWRAFVEDLSVNPGELGDVVGELRVFLMPYASVARAI

Download         Length: 864 bp

>T166170 NZ_CP074052:2179348-2179451 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 206 a.a.        Molecular weight: 22185.64 Da        Isoelectric Point: 7.9511

>AT166170 WP_213163967.1 NZ_CP058214:c1826397-1825780 [Kaustia mangrovi]
MPQTPSQREIAHDLLATHGILRLAELRDAGVTAATVSRMEKDGEVIRLARGLYQLPDAELDANHSLAEAAKRFPKGVICL
VSALAFHGLTDQLPKKVWMAIGRNDWTPKPSDMPIRVLRFSDDLLADSVETHVIEGVSVKVFGVAKTVADCFRHRGKIGL
PVALEGLQEALRQRKATPAEIARAADIGGVGTVIRPYLEALTANG

Download         Length: 618 bp

>AT166170 NZ_CP074052:c2179489-2179218 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References