Detailed information of TA system TA166167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4759287..4760106
• Replicon: chromosome
• Accession: NZ_CP058212
• Organism: Klebsiella michiganensis strain RHB20-C02

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: HVX57_RS22410
• Protein ID: WP_004110819.1
• Coordinates: 4759849..4760106 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: HVX57_RS22405
• Protein ID: WP_181251206.1
• Coordinates: 4759287..4759838 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HVX57_RS22390	4754657..4756054	+	1398	WP_014228060.1	MFS transporter	-
HVX57_RS22395	4756176..4757516	+	1341	WP_032748099.1	carbohydrate porin	-
HVX57_RS22400	4757641..4759269	-	1629	WP_181251800.1	SAM-dependent methyltransferase	-
HVX57_RS22405	4759287..4759838	-	552	WP_181251206.1	N-acetyltransferase	Antitoxin
HVX57_RS22410	4759849..4760106	-	258	WP_004110819.1	YjhX family toxin	Toxin
HVX57_RS22415	4760782..4761966	+	1185	WP_014228054.1	mannonate dehydratase	-
HVX57_RS22420	4762040..4763515	+	1476	WP_014228053.1	fructuronate reductase	-
HVX57_RS22425	4763654..4764430	+	777	WP_004847986.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T166167 WP_004110819.1 NZ_CP058212:c4760106-4759849 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T166167 NZ_CP074052:1103229-1103564 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19962.69 Da
• Isoelectric Point: 6.4913

>AT166167 WP_181251206.1 NZ_CP058212:c4759838-4759287 [Klebsiella michiganensis]
MTNHSFTFHVTSEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLTVVPEYQGAGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRHGFEPGAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT166167 NZ_CP074052:1102981-1103229 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCTCCTGCAGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGAAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2