Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 873512..874169 Replicon chromosome
Accession NZ_CP058212
Organism Klebsiella michiganensis strain RHB20-C02

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag HVX57_RS04210 Protein ID WP_004854060.1
Coordinates 873759..874169 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag HVX57_RS04205 Protein ID WP_004124953.1
Coordinates 873512..873778 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVX57_RS04190 868746..869171 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
HVX57_RS04195 869292..872090 - 2799 WP_049079129.1 transcriptional regulator DagR -
HVX57_RS04200 872284..873267 - 984 WP_181251431.1 tRNA-modifying protein YgfZ -
HVX57_RS04205 873512..873778 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
HVX57_RS04210 873759..874169 + 411 WP_004854060.1 protein YgfX Toxin
HVX57_RS04215 874178..874699 - 522 WP_143440241.1 flavodoxin FldB -
HVX57_RS04220 874821..875717 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
HVX57_RS04225 875740..876453 + 714 WP_064381439.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVX57_RS04230 876459..878192 + 1734 WP_032751182.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T166156 WP_004854060.1 NZ_CP058212:873759-874169 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

>T166156 NZ_CP074047:c4006900-4006613 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT166156 WP_004124953.1 NZ_CP058212:873512-873778 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT166156 NZ_CP074047:c4006626-4006324 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References