Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3789581..3790232 Replicon chromosome
Accession NZ_CP058209
Organism Escherichia marmotae strain RHB24-C12

Toxin (Protein)


Gene name cptA Uniprot ID A0A370V2T3
Locus tag HVY12_RS18345 Protein ID WP_000244789.1
Coordinates 3789581..3789985 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U9H610
Locus tag HVY12_RS18350 Protein ID WP_000354045.1
Coordinates 3789966..3790232 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVY12_RS18325 3785545..3787278 - 1734 WP_000813173.1 single-stranded-DNA-specific exonuclease RecJ -
HVY12_RS18330 3787284..3787994 - 711 WP_000715232.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVY12_RS18335 3788019..3788915 - 897 WP_000806649.1 site-specific tyrosine recombinase XerD -
HVY12_RS18340 3789026..3789547 + 522 WP_001055874.1 flavodoxin FldB -
HVY12_RS18345 3789581..3789985 - 405 WP_000244789.1 protein YgfX Toxin
HVY12_RS18350 3789966..3790232 - 267 WP_000354045.1 FAD assembly factor SdhE Antitoxin
HVY12_RS18355 3790485..3791465 + 981 WP_000886070.1 tRNA-modifying protein YgfZ -
HVY12_RS18360 3791612..3792271 - 660 WP_001517030.1 hemolysin III family protein -
HVY12_RS18365 3792434..3792745 - 312 WP_001182960.1 N(4)-acetylcytidine aminohydrolase -
HVY12_RS18370 3792790..3794223 + 1434 WP_181237695.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15987.93 Da        Isoelectric Point: 11.5202

>T166143 WP_000244789.1 NZ_CP058209:c3789985-3789581 [Escherichia marmotae]
VVLWQSELRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWLVLLSLVVFDCVRSQRRINSRQGEIRLLMDGRLRWQGQ
EWSIVKTPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIR

Download         Length: 405 bp

>T166143 NZ_CP074047:855777-856184 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10533.09 Da        Isoelectric Point: 5.1496

>AT166143 WP_000354045.1 NZ_CP058209:c3790232-3789966 [Escherichia marmotae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT166143 NZ_CP074047:855530-855796 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A370V2T3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H610

References