Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1070289..1070760 | Replicon | chromosome |
| Accession | NZ_CP058209 | ||
| Organism | Escherichia marmotae strain RHB24-C12 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | HVY12_RS05560 | Protein ID | WP_001303511.1 |
| Coordinates | 1070482..1070760 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | HVY12_RS05555 | Protein ID | WP_001302048.1 |
| Coordinates | 1070289..1070480 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HVY12_RS05500 | 1065367..1065726 | - | 360 | WP_063123852.1 | hypothetical protein | - |
| HVY12_RS05505 | 1065723..1065899 | - | 177 | WP_000753067.1 | hypothetical protein | - |
| HVY12_RS05510 | 1065892..1066074 | - | 183 | WP_024238437.1 | hypothetical protein | - |
| HVY12_RS05515 | 1066170..1066694 | - | 525 | WP_097333611.1 | ead/Ea22-like family protein | - |
| HVY12_RS05520 | 1066681..1066947 | - | 267 | WP_000004320.1 | hypothetical protein | - |
| HVY12_RS05525 | 1066944..1067336 | - | 393 | WP_181237996.1 | DUF977 family protein | - |
| HVY12_RS05530 | 1067351..1068097 | - | 747 | WP_181237997.1 | ATP-binding protein | - |
| HVY12_RS05535 | 1068104..1069051 | - | 948 | WP_089569406.1 | helix-turn-helix domain-containing protein | - |
| HVY12_RS05540 | 1069075..1069500 | - | 426 | WP_053272758.1 | Rha family transcriptional regulator | - |
| HVY12_RS05545 | 1069497..1069799 | - | 303 | WP_000172735.1 | transcriptional regulator | - |
| HVY12_RS05550 | 1069897..1070268 | + | 372 | WP_001169685.1 | hypothetical protein | - |
| HVY12_RS05555 | 1070289..1070480 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| HVY12_RS05560 | 1070482..1070760 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HVY12_RS05565 | 1071044..1071196 | + | 153 | WP_000379570.1 | DUF1391 family protein | - |
| HVY12_RS05570 | 1071208..1071582 | + | 375 | WP_181237998.1 | hypothetical protein | - |
| HVY12_RS05575 | 1071661..1072107 | - | 447 | WP_181237999.1 | hypothetical protein | - |
| HVY12_RS05580 | 1072796..1072984 | + | 189 | WP_042973094.1 | cell division inhibition protein DicB | - |
| HVY12_RS05585 | 1072981..1073184 | + | 204 | WP_001090192.1 | DUF1482 family protein | - |
| HVY12_RS05590 | 1073262..1074047 | + | 786 | Protein_1098 | exonuclease | - |
| HVY12_RS05595 | 1074146..1074901 | - | 756 | WP_001282653.1 | IS21-like element ISSso4 family helper ATPase IstB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1032972..1080732 | 47760 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T166137 WP_001303511.1 NZ_CP058209:1070482-1070760 [Escherichia marmotae]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T166137 NZ_CP074042:c4447231-4446920 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT166137 WP_001302048.1 NZ_CP058209:1070289-1070480 [Escherichia marmotae]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT166137 NZ_CP074042:c4446919-4446629 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|