Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3658533..3659184 Replicon chromosome
Accession NZ_CP058207
Organism Escherichia marmotae strain RHB42-C09

Toxin (Protein)


Gene name cptA Uniprot ID A0A370V2T3
Locus tag HV018_RS17315 Protein ID WP_000244789.1
Coordinates 3658533..3658937 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U9H610
Locus tag HV018_RS17320 Protein ID WP_000354045.1
Coordinates 3658918..3659184 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV018_RS17295 3654497..3656230 - 1734 WP_179309313.1 single-stranded-DNA-specific exonuclease RecJ -
HV018_RS17300 3656236..3656946 - 711 WP_179309312.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV018_RS17305 3656971..3657867 - 897 WP_000806649.1 site-specific tyrosine recombinase XerD -
HV018_RS17310 3657978..3658499 + 522 WP_001055874.1 flavodoxin FldB -
HV018_RS17315 3658533..3658937 - 405 WP_000244789.1 protein YgfX Toxin
HV018_RS17320 3658918..3659184 - 267 WP_000354045.1 FAD assembly factor SdhE Antitoxin
HV018_RS17325 3659437..3660417 + 981 WP_000886070.1 tRNA-modifying protein YgfZ -
HV018_RS17330 3660564..3661223 - 660 WP_001517030.1 hemolysin III family protein -
HV018_RS17335 3661386..3661697 - 312 WP_001182960.1 N(4)-acetylcytidine aminohydrolase -
HV018_RS17340 3661742..3663175 + 1434 WP_001517031.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15987.93 Da        Isoelectric Point: 11.5202

>T166118 WP_000244789.1 NZ_CP058207:c3658937-3658533 [Escherichia marmotae]
VVLWQSELRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWLVLLSLVVFDCVRSQRRINSRQGEIRLLMDGRLRWQGQ
EWSIVKTPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIR

Download         Length: 405 bp

>T166118 NZ_CP074036:44904-45056 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10533.09 Da        Isoelectric Point: 5.1496

>AT166118 WP_000354045.1 NZ_CP058207:c3659184-3658918 [Escherichia marmotae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT166118 NZ_CP074036:c44854-44792 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A370V2T3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H610

References