Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2376561..2377199 Replicon chromosome
Accession NZ_CP058207
Organism Escherichia marmotae strain RHB42-C09

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag HV018_RS11160 Protein ID WP_000813795.1
Coordinates 2377023..2377199 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HV018_RS11155 Protein ID WP_077627724.1
Coordinates 2376561..2376977 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV018_RS11135 2371716..2372657 - 942 WP_001516417.1 ABC transporter permease -
HV018_RS11140 2372658..2373671 - 1014 WP_016248715.1 ABC transporter ATP-binding protein -
HV018_RS11145 2373689..2374834 - 1146 WP_181236669.1 ABC transporter substrate-binding protein -
HV018_RS11150 2375073..2376482 - 1410 WP_000760662.1 PLP-dependent aminotransferase family protein -
HV018_RS11155 2376561..2376977 - 417 WP_077627724.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HV018_RS11160 2377023..2377199 - 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HV018_RS11165 2377421..2377651 + 231 WP_000494240.1 DUF2554 family protein -
HV018_RS11170 2377745..2379706 - 1962 WP_024191881.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HV018_RS11175 2379779..2380315 - 537 WP_000429073.1 XRE family transcriptional regulator -
HV018_RS11180 2380368..2381579 + 1212 WP_071990339.1 benzoate/H(+) symporter BenE family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T166115 WP_000813795.1 NZ_CP058207:c2377199-2377023 [Escherichia marmotae]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T166115 NZ_CP074034:95690-95839 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTTACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15250.62 Da        Isoelectric Point: 4.5908

>AT166115 WP_077627724.1 NZ_CP058207:c2376977-2376561 [Escherichia marmotae]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNNNDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT166115 NZ_CP074034:c95646-95585 [Escherichia coli]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References