Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2291385..2292973 Replicon chromosome
Accession NZ_CP058207
Organism Escherichia marmotae strain RHB42-C09

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HV018_RS10810 Protein ID WP_181237432.1
Coordinates 2291651..2292973 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HV018_RS10805 Protein ID WP_001516368.1
Coordinates 2291385..2291651 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV018_RS10790 2288062..2288976 + 915 WP_001516366.1 bestrophin family protein -
HV018_RS10795 2288980..2289738 - 759 WP_016262005.1 trans-aconitate 2-methyltransferase -
HV018_RS10800 2290165..2291121 + 957 WP_000197006.1 hypothetical protein -
HV018_RS10805 2291385..2291651 + 267 WP_001516368.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HV018_RS10810 2291651..2292973 + 1323 WP_181237432.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
HV018_RS10815 2293244..2294176 - 933 WP_181237433.1 hypothetical protein -
HV018_RS10820 2294412..2295812 - 1401 WP_181237434.1 ISNCY family transposase -
HV018_RS10825 2296189..2296314 + 126 Protein_2111 AraC family transcriptional regulator -
HV018_RS10830 2296371..2297339 - 969 WP_181237435.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2291385..2300615 9230


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49571.18 Da        Isoelectric Point: 8.5841

>T166113 WP_181237432.1 NZ_CP058207:2291651-2292973 [Escherichia marmotae]
MPKLVTWMNNQRVGELTKLTNGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNQLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPEDETVTRPIMVWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRMGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKEFGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGSTDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGRKTEIDKIYPRHFLATAKALKFPEVQMHEILSDFARMIP
AALDNVKASLPADFPENVLTAIETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

>T166113 NZ_CP074034:35090-35395 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10034.37 Da        Isoelectric Point: 4.5668

>AT166113 WP_001516368.1 NZ_CP058207:2291385-2291651 [Escherichia marmotae]
MMSFPMIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLNLSMTLCDTKNDSPES
TDQQDLEW

Download         Length: 267 bp

>AT166113 NZ_CP074034:34870-35088 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References