Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 72110..73020 Replicon plasmid pRHBSTW-00002_3
Accession NZ_CP058198
Organism Enterobacter roggenkampii strain RHBSTW-00002

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag HV027_RS23160 Protein ID WP_004883378.1
Coordinates 72110..72580 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7H4PRG4
Locus tag HV027_RS23165 Protein ID WP_032413443.1
Coordinates 72577..73020 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV027_RS23145 68333..69298 - 966 WP_023328925.1 L-Ala-D/L-Glu epimerase -
HV027_RS23150 69300..70307 - 1008 WP_032413314.1 DUF1611 domain-containing protein -
HV027_RS23155 70792..72000 + 1209 WP_015386429.1 IS256 family transposase -
HV027_RS23160 72110..72580 - 471 WP_004883378.1 RES family NAD+ phosphorylase Toxin
HV027_RS23165 72577..73020 - 444 WP_032413443.1 DUF2384 domain-containing protein Antitoxin
HV027_RS23170 73121..73350 - 230 Protein_68 DUF4113 domain-containing protein -
HV027_RS23175 73391..73708 + 318 Protein_69 transposase -
HV027_RS23180 73922..74341 - 420 WP_011251286.1 helix-turn-helix domain-containing protein -
HV027_RS23185 74338..74649 - 312 WP_011251285.1 type II toxin-antitoxin system HigB family toxin -
HV027_RS23190 74854..75914 - 1061 Protein_72 IS3 family transposase -
HV027_RS23195 75964..76380 - 417 WP_057072957.1 type II toxin-antitoxin system VapC family toxin -
HV027_RS23200 76377..76607 - 231 WP_057072956.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..108466 108466


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 23124.74 Da        Isoelectric Point: 5.5500

>T166096 WP_004883378.1 NZ_CP058198:c72580-72110 [Enterobacter roggenkampii]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 471 bp

>T166096 NZ_CP074033:1056437-1056544 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 21800.15 Da        Isoelectric Point: 5.5500

>AT166096 WP_032413443.1 NZ_CP058198:c73020-72577 [Enterobacter roggenkampii]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 444 bp

>AT166096 NZ_CP074033:c1056381-1056325 [Escherichia coli]
TCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7H4PRG4

References