Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 81287..81813 Replicon plasmid pRHBSTW-00012_2
Accession NZ_CP058192
Organism Enterobacter hormaechei strain RHBSTW-00012

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HV033_RS24090 Protein ID WP_000323025.1
Coordinates 81526..81813 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag HV033_RS24085 Protein ID WP_004196370.1
Coordinates 81287..81526 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV033_RS24055 76624..76816 - 193 Protein_81 MFS transporter -
HV033_RS24060 76846..77823 + 978 WP_004196334.1 chromate resistance protein -
HV033_RS24065 77780..79156 + 1377 WP_004196363.1 chromate efflux transporter -
HV033_RS24070 79187..79876 - 690 WP_004196322.1 hypothetical protein -
HV033_RS24075 79890..80627 - 738 WP_008460272.1 HupE/UreJ family protein -
HV033_RS24080 80671..81036 - 366 WP_009651956.1 hypothetical protein -
HV033_RS24085 81287..81526 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HV033_RS24090 81526..81813 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HV033_RS24095 81885..82043 + 159 WP_013087178.1 type I toxin-antitoxin system Hok family toxin -
HV033_RS24100 82922..83236 + 315 WP_023338051.1 hypothetical protein -
HV033_RS24105 83296..83757 + 462 WP_048974901.1 hypothetical protein -
HV033_RS24110 83847..84047 + 201 WP_031494497.1 hypothetical protein -
HV033_RS24115 84088..84879 + 792 WP_032663722.1 N-6 DNA methylase -
HV033_RS24120 84922..85257 + 336 WP_023345479.1 hypothetical protein -
HV033_RS24125 85947..86240 + 294 WP_032663725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..141272 141272


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T166093 WP_000323025.1 NZ_CP058192:81526-81813 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T166093 NZ_CP074033:98034-98288 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGTTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT166093 WP_004196370.1 NZ_CP058192:81287-81526 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT166093 NZ_CP074033:97786-98037 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References