Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4838147..4838763 Replicon chromosome
Accession NZ_CP058191
Organism Enterobacter hormaechei strain RHBSTW-00012

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV033_RS23260 Protein ID WP_080339264.1
Coordinates 4838147..4838518 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag HV033_RS23265 Protein ID WP_023298920.1
Coordinates 4838521..4838763 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV033_RS23245 4835647..4836549 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
HV033_RS23250 4836546..4837181 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
HV033_RS23255 4837178..4838107 + 930 WP_063146851.1 formate dehydrogenase accessory protein FdhE -
HV033_RS23260 4838147..4838518 - 372 WP_080339264.1 type II toxin-antitoxin system VapC family toxin Toxin
HV033_RS23265 4838521..4838763 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
HV033_RS23270 4838963..4839883 + 921 WP_063146850.1 alpha/beta hydrolase -
HV033_RS23275 4839892..4840833 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
HV033_RS23280 4840878..4841315 - 438 WP_063146849.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV033_RS23285 4841312..4842193 - 882 WP_023298923.1 virulence factor BrkB family protein -
HV033_RS23290 4842187..4842786 - 600 WP_003861947.1 glucose-1-phosphatase -
HV033_RS23295 4842905..4843705 - 801 WP_023298924.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4828370..4839883 11513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13596.66 Da        Isoelectric Point: 6.4866

>T166091 WP_080339264.1 NZ_CP058191:c4838518-4838147 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T166091 NZ_CP074032:74358-74756 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT166091 WP_023298920.1 NZ_CP058191:c4838763-4838521 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT166091 NZ_CP074032:74131-74358 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References